Evidence map›Paper›PMID 39503930›Full record

ArticleGenes & genomics2025

Analysis of key pathways and genes in nodal structure on rat skin surface using gene ontology and KEGG pathway.

Joonyoung Shin, A Yeong Park, Suk Ju, Hyorin Lee, Hyung Won Kang, Dongwoon Han, Sungchul Kim

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Article in Genes & genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Joonyoung ShinInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea.ORCID 0000-0002-5064-6227
A Yeong ParkInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea.ORCID 0009-0003-2312-1200
Suk JuInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea.ORCID 0009-0000-1469-999X
Hyorin LeeInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea.ORCID 0009-0008-7283-2929
Hyung Won KangInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea.ORCID 0000-0001-6497-0100
Dongwoon HanInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea.ORCID 0000-0003-0206-8976
Sungchul KimInstitute for Global Rare Disease Network, Professional Graduate School of Korean Medicine, Wonkwang University, 460 Iksan-daero, Iksan, 54538, Republic of Korea. kscndl@naver.com.ORCID 0009-0002-9513-0758

Funding

Wonkwang University 2022
6 · The paper itself

Abstract

backgroundWe have previously reported anatomical, histological, and gene expression characteristics of the nodal structure of rat skin surface and suggested its potential as an acupuncture point. However, the specific characteristics of the interactions among the genes expressed in this structure remain unclear.

objectiveWe aimed to determine gene expression changes by analyzing interaction networks of genes up-regulated in nodal structures and to explore relationships with acupuncture points.

methodsWe investigated the relationship between the nodal structures and acupuncture points by analyzing the interactions of up-regulated genes, their Gene Ontology biological functions, and the characteristics of Kyoto Encyclopedia of Genes and Genomes pathways. RNA-seq and STRING analysis provided comprehensive information on these gene groups.

resultsInteractions between up-regulated genes in nodal structures were classified into three groups. The first group, which includes Wnt7b, Wnt3, and Wnt16, showed significant interactions in pathways such as Wnt signaling, Alzheimer's disease, and regulation of stem cell pluripotency. The second group, composed of Fos, Dusp1, Pla2g4e, Pla2g4f, and Fgfr3, demonstrated a notable association with the MAPK signaling pathway. Lastly, the third group, consisting of Adcy1, Pla2g4e, Pla2g4f, and Dusp1 exhibited effective interactions with the inflammatory mediator regulation of TRP channels and serotonergic synapse.

conclusionContinued research on nodal structures where these genes are expressed is needed to improve our understanding of skin anatomy and physiology as well as their potential clinical utility as acupuncture points.

Indexed as

SkinAcupuncture PointsAnimalsGene Expression ProfilingGene OntologyGene Regulatory NetworksRatsSignal TransductionAcupuncture pointsKEGG pathwaysNodal structureRegulation of stem cell pluripotencyWnt signaling

Identifiers

PMID39503930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.