Utility of preoperative prophylactic antibiotics for preventing surgical site infections in children with infantile hypertrophic pyloric stenosis: a systematic review and meta-analysis.

Annu Gulia, Hemant Khandelia, Vikas Dhikav, Sachit Anand

Abstract readMeta-AnalysisSystematic Review

In one paragraph

Synthesis in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Annu GuliaAll India Institute of Medical Sciences, New Delhi, India.

Hemant KhandeliaAll India Institute of Medical Sciences, New Delhi, India.

Vikas DhikavDepartment of Health Research, Ministry of Health and Family Welfare, Government of India, New Delhi, India.

Sachit AnandAll India Institute of Medical Sciences, New Delhi, India. kanu.sachit@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe aim of this study was to determine the utility of prophylactic antibiotics before pyloromyotomy for the prevention of Surgical Site Infections (SSI) among children with Infantile Hypertrophic Pyloric Stenosis (IHPS).

methodsA systematic search of PubMed, Scopus, Embase, and Web of Science databases was performed to identify papers published till 30th July 2024. The main outcome of interest was the incidence of SSIs. The relative risk (RR) with 95% confidence interval (CI) was calculated using a random effects model. The I

resultsFive studies, published between 1999 and 2024, were included in this systematic review and meta-analysis. The risk of developing SSI among those treated was RR = 0.97, 95% CI 0.53 to 1.78, with I

conclusionThe findings of this review demonstrate no incremental benefit of the administration of prophylactic antibiotics before pyloromyotomy in preventing SSIs in children with IHPS. However, randomized, double-blinded, placebo-controlled trials need to be conducted in the future before any definite conclusions are drawn in this regard.

Indexed as

Antibiotic ProphylaxisPyloric Stenosis, HypertrophicSurgical Wound InfectionAnti-Bacterial AgentsHumansInfantInfant, NewbornPreoperative CarePyloromyotomyAnti-Bacterial AgentsInfantile hypertrophic pyloric stenosisProphylactic antibioticsPyloromyotomySurgical site infections

Identifiers

PMID39503899

DOI10.1007/s00383-024-05883-x

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.