Evidence map›Paper›PMID 39503787›Full record

ArticlePediatric surgery international2024

Clinical translation of tissue-engineered oesophageal grafts: are patients ready for us?

N Durkin, M Pellegrini, V Karaluka, G Slater, D Leyden, S Eaton, Paolo De Coppi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric surgery international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

N DurkinStem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Zayed Centre for Research Into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK.
M PellegriniStem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Zayed Centre for Research Into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK.
V KaralukaNIHR GOSH Biomedical Research Centre, Great Ormond Street Hospital, London, UK.
G SlaterTracheo-Oesophageal Fistula Support (TOFS) Charity, Nottingham, UK.
D LeydenNIHR GOSH Biomedical Research Centre, Great Ormond Street Hospital, London, UK.
S EatonStem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Zayed Centre for Research Into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK.
Paolo De CoppiStem Cell and Regenerative Medicine Section, Developmental Biology and Cancer Research and Teaching Department, Zayed Centre for Research Into Rare Disease in Children, UCL Great Ormond Street Institute of Child Health, London, UK. p.decoppi@ucl.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe sought to engage with expert patient/carers to understand attitudes towards use of tissue engineering (TE) for long-gap oesophageal atresia (OA).

methodsAn in-person engagement event for 70 patients/parents was held by the OA patient group, TOFS. Attitudes towards TE were assessed before and after a talk on use of TE oesophagi in a pre-clinical OA model. Perceptions were assessed using a 5-point Likert scale (median [range]) and compared using Mann-Whitney test.

results43 attendees responded; 56% parents/caregivers, 21% patients, 7% healthcare workers, 16% unreported. Most (85%) had some awareness of TE but for 15%, it was a new concept. Attendees were receptive to TE; 89% reported no concerns about growth of their/child(s) cells in a lab and 61% reported no concerns about using animal products. Perceptions of TE significantly improved after the presentation from 4 (2-5, n = 32) to 5 (3-5, n = 28) p < 0.0001, and 96% would like to be involved in focus groups on development of a TE product for use in OA.

conclusionInput from key stakeholders is essential to introduction of TE constructs clinically. The overall response to TE constructs was positive, and informs development of an OA-specific focus group to guide translation.

Indexed as

Esophageal AtresiaEsophagusTissue EngineeringFemaleHumansMaleParentsTranslational Research, BiomedicalOesophageal atresiaPatient and public involvementTissue engineering

Identifiers

PMID39503787
PMCPMC11541389

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.