Evidence map›Paper›PMID 39503503›Full record

ArticlemSphere2024

Pneumococcal extracellular vesicles mediate horizontal gene transfer via the transformation machinery.

Sarah Werner Lass, Bailey E Smith, Shaw Camphire, Rory A Eutsey, Jojo A Prentice, Saigopalakrishna S Yerneni, Ashni Arun, Andrew A Bridges, Jason W Rosch, James F Conway and 2 more

Abstract read
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Membrane Vesicles ofMicroorganisms · 2025
    Article
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Sarah Werner Lass *Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Bailey E Smith *Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-4613-734X
Shaw Camphire *Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-8004-2152
Rory A EutseyDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Jojo A PrenticeDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Saigopalakrishna S YerneniDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Ashni ArunDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.
Andrew A BridgesDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-8132-751X
Jason W RoschDepartment of Host-Microbe Interactions, St Jude Children's Research Hospital, Memphis, Tennessee, USA.ORCID 0000-0002-1798-1760
James F ConwayDepartment of Structural Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6581-4748
Phil CampbellDepartment of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.ORCID 0000-0003-4309-250X
N Luisa HillerDepartment of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6572-1368

Funding

Cryo-electron microscopeS10OD025009 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONWAY, JAMES F. · 2018 to 2018
$2.0M
Interinstitutional Program in Cell and Molecular Biology: A Graduate Training Path to Promote Traditional and Non-Traditional Professional OutcomesT32GM133353 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BRODSKY, JEFFREY L., MURRAY, SANDRA ANN · 2020 to 2024
$1.5M
This way out: Spatiotemporal regulation of Vibrio cholerae biofilm dispersalR00AI158939 · NIAID · CARNEGIE-MELLON UNIVERSITY · PI BRIDGES, ANDREW A. · 2023 to 2024
$498k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) 5T32GM133353-04NIAID NIH HHS R00 AI158939NIGMS NIH HHS T32 GM133353NIH HHS S10 OD025009NSF | National Science Foundation Graduate Research Fellowship Program (GRFP)ODCDC CDC HHS S10 OD025009Shurl and Kay Curci Foundation (SKCF)
6 · The paper itself

Abstract

Bacterial cells secrete extracellular vesicles (EVs), the function of which is a matter of intense investigation. Here, we show that the EVs secreted by the human pathogen

Indexed as

DNA, BacterialExtracellular VesiclesGene Transfer, HorizontalStreptococcus pneumoniaeTransformation, BacterialDrug Resistance, BacterialHumansDNA, Bacterialantibiotic resistancecompetenceextracellular vesiclehorizontal gene transferStreptococcus pneumoniaetransformation

Identifiers

PMID39503503
PMCPMC11656791

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.