Evidence map›Paper›PMID 39503502›Full record

ArticleJournal of clinical microbiology2024

Prospective evaluation of non-invasive saliva specimens for the diagnosis of syphilis and molecular surveillance of

Kazuo Imai, Akihiro Sato, Masashi Tanaka, Yuki Ohama, Shu-Ichi Nakayama, Ryuha Omachi, Keita Takeuchi, Norihito Tarumoto, Mieko Tokano, Shigefumi Mesaki and 2 more

Abstract readEvaluation Study
In one paragraph

Article in Journal of clinical microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kazuo ImaiDepartment of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.ORCID 0000-0002-8416-7371
Akihiro SatoKARADA Internal Medicine Clinic, Tokyo, Japan.
Masashi TanakaKARADA Internal Medicine Clinic Shibuya, Tokyo, Japan.
Yuki OhamaDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.
Shu-Ichi NakayamaDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.ORCID 0000-0002-1495-0926
Ryuha OmachiDepartment of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.
Keita TakeuchiDepartment of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.
Norihito TarumotoDepartment of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan.ORCID 0000-0002-5866-8877
Mieko TokanoDepartment of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan.
Shigefumi MesakiDepartment of Infectious Disease and Infection Control, Saitama Medical University, Saitama, Japan.
Takuya MaedaDepartment of Clinical Laboratory, Saitama Medical University Hospital, Saitama, Japan.ORCID 0000-0003-0912-4643
Yukihiro AkedaDepartment of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan.ORCID 0000-0002-5325-4173

Funding

Japan Agency for Medical Research and Development (AMED) 23fk0108676,24fk0108676
6 · The paper itself

Abstract

The promising diagnostic performance of molecular testing for syphilis using saliva and urine samples has been reported; however, further evaluation of its possible application for diagnosis and molecular surveillance is required. In addition, the development of a rapid and easy-to-perform molecular test for syphilis is important for its use in the clinical setting. We comprehensively evaluated the diagnostic and surveillance performance of two novel loop-mediated isothermal amplification (LAMP) assays using saliva and urine samples. Saliva, urine, and whole blood were collected from patients who underwent serological testing for syphilis at outpatient clinics.

Indexed as

DNA, BacterialMolecular Diagnostic TechniquesNucleic Acid Amplification TechniquesSalivaSensitivity and SpecificitySyphilisTreponema pallidumAdultAgedFemaleGenotypeHumansMaleMiddle AgedMultilocus Sequence TypingProspective StudiesDNA, BacterialLAMPMLSTPCRsalivasyphilisTreponema

Identifiers

PMID39503502
PMCPMC11633093

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.