Evidence map›Paper›PMID 39503488›Full record

SynthesisAntimicrobial agents and chemotherapy2024

Fidaxomicin resistance in

ThanhPhuong M Le, Taryn A Eubank, Ann M McKelvey, Xinyun Cao, Julian G Hurdle, Kevin W Garey

Abstract readSystematic Review
In one paragraph

Synthesis in Antimicrobial agents and chemotherapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. A sensitive and reduced-cost culture medium for recovery ofJournal of clinical microbiology · 2026
    Article
  5. Biomedicines · 2025
    Review
  6. Emergence and Spread of Clostridioides difficile Isolates With Reduced Fidaxomicin Susceptibility in an Acute Care Hospital.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

ThanhPhuong M LeDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0002-5312-6366
Taryn A EubankDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0002-6645-406X
Ann M McKelveyDepartment of Translational Medical Sciences, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.ORCID 0000-0003-4767-8866
Xinyun CaoDepartment of Microbiology, UT Southwestern Medical Center, Dallas, Texas, USA.ORCID 0000-0002-7346-3909
Julian G HurdleDepartment of Translational Medical Sciences, Center for Infectious and Inflammatory Diseases, Institute of Biosciences and Technology, Texas A&M Health Science Center, Houston, Texas, USA.ORCID 0000-0003-2214-8105
Kevin W GareyDepartment of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.ORCID 0000-0003-2063-7503

Funding

Diversity Supplement: Decoding the clinical impact of the recent evolution of metronidazole resistance on Clostridium difficile infectionR01AI139261 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Kevin W Garey, Julian G Hurdle · 2018 to 2026
$6.0M
High Throughput Screening for Non-antibiotic inhibitors of Clostridium difficile PathophysiologyR01AI144459 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI HURDLE, JULIAN G · 2019 to 2022
$2.4M
Texas Medical Center Training Program in Antimicrobial ResistanceT32AI141349 · NIAID · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI GARSIN, DANIELLE A · 2019 to 2023
$1.3M
HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) 2R01AI139261HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID) T32 A1141349NIAID NIH HHS R01 AI139261NIAID NIH HHS R01 AI144459NIAID NIH HHS T32 AI141349
6 · The paper itself

Abstract

Fidaxomicin (FDX), an RNA polymerase (RNAP) inhibitor antibiotic, is a guideline-recommended therapy for

Indexed as

Anti-Bacterial AgentsClostridioides difficileDNA-Directed RNA PolymerasesDrug Resistance, BacterialFidaxomicinMicrobial Sensitivity TestsBacterial ProteinsBinding SitesClostridium InfectionsHumansMutationPolymorphism, Single NucleotideAnti-Bacterial AgentsBacterial ProteinsDNA-Directed RNA PolymerasesFidaxomicinantimicrobial resistancemacrocyclic antibioticsRNA polymerase

Identifiers

PMID39503488
PMCPMC11619340

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.