Evidence map›Paper›PMID 39503302›Full record

ArticleNMR in biomedicine2025

Simultaneous assessment of cerebral glucose and oxygen metabolism and perfusion in rats using interleaved deuterium (

Guangle Zhang, Parker Jenkins, Wei Zhu, Wei Chen, Xiao-Hong Zhu

Abstract read
In one paragraph

Article in NMR in biomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Guangle ZhangCenter for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Parker JenkinsCenter for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Wei ZhuCenter for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.
Wei ChenCenter for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-9608-1444
Xiao-Hong ZhuCenter for Magnetic Resonance Research (CMRR), Department of Radiology, University of Minnesota, Minneapolis, Minnesota, USA.

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Mehmet Akcakaya · 2019 to 2026
$11.7M
Integrated fMRI Methods to Study Neurophysiology and Circuit Dynamics at Laminar and Columnar LevelR01MH111413 · NIMH · UNIVERSITY OF MINNESOTA · PI CHEN, WEI · 2016 to 2020
$4.4M
Development of Quantitative Deuterium MRS Imaging for Human Brain Tumor Application at Ultrahigh FieldR01CA240953 · NCI · UNIVERSITY OF MINNESOTA · PI CHEN, WEI, LIANG, ZHI-PEI · 2019 to 2025
$2.7M
Establishing translational neuroimaging tools for quantitative assessment of energy metabolism and metabolic reprogramming in healthy and diseased human brain at 7TR01NS133006 · NINDS · UNIVERSITY OF MINNESOTA · PI Wei Chen, XIAO-HONG ZHU · 2023 to 2026
$2.5M
Ultra High Field (16.4 Tesla) Animal MRI/MRS SystemS10RR025031 · NCRR · UNIVERSITY OF MINNESOTA · PI GARWOOD, MICHAEL · 2008 to 2008
$2.0M
NCI NIH HHS R01 CA240953NCRR NIH HHS S10 RR025031NIBIB NIH HHS P41 EB027061NIMH NIH HHS R01 MH111413NINDS NIH HHS R01 NS133006
6 · The paper itself

Abstract

Cerebral glucose and oxygen metabolism and blood perfusion play key roles in neuroenergetics and oxidative phosphorylation to produce adenosine triphosphate (ATP) energy molecules in supporting cellular activity and brain function. Their impairments have been linked to numerous brain disorders. This study aimed to develop an in vivo magnetic resonance spectroscopy (MRS) method capable of simultaneously assessing and quantifying the major cerebral metabolic rates of glucose (CMR

Indexed as

BrainCerebrovascular CirculationDeuteriumGlucoseMagnetic Resonance SpectroscopyOxygenRats, Sprague-DawleyAnimalsMaleOxygen IsotopesRatsDeuteriumGlucoseOxygenOxygen-17Oxygen Isotopesbrain energy metabolism and perfusioninterleaved 2H–17O MRS techniquemultifrequency RF surface coilultrahigh fieldX‐nuclear MRS and imaging

Identifiers

PMID39503302
PMCPMC11602644

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.