Evidence map›Paper›PMID 39503063›Full record

SynthesisNursing in critical care2025

Non-pharmacological interventions to support the cognitive rehabilitation of patients admitted to the intensive care unit: An umbrella review.

Anna Holm, Linette Thorn, Anette Bjerregaard Alrø, Helene Korvenius Nedergaard, Hanne Irene Jensen, Pia Dreyer

Abstract readSystematic Review
In one paragraph

Synthesis in Nursing in critical care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Anna HolmDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-2582-4984
Linette ThornDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-8743-2962
Anette Bjerregaard AlrøDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0001-9600-5006
Helene Korvenius NedergaardDepartment of Anaesthesiology and Intensive Care, Kolding Hospital, University Hospital of Southern Denmark, Kolding, Denmark.ORCID https://orcid.org/0000-0002-5988-4563
Hanne Irene JensenDepartment of Anaesthesiology and Intensive Care, Kolding Hospital, University Hospital of Southern Denmark, Kolding, Denmark.ORCID https://orcid.org/0000-0001-9323-4284
Pia DreyerDepartment of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.ORCID https://orcid.org/0000-0002-3581-7438

Funding

The Novo Nordisk Foundation
6 · The paper itself

Abstract

backgroundCritically ill patients experience cognitive impairment throughout their intensive care unit trajectory, in the acute phase and the long-term alike. Cognitive impairment may negatively impact patients' quality of life and rehabilitation outcomes.

aimTo provide an overall examination of literature concerning non-pharmacological interventions that can enhance cognitive functioning in critically ill patients or facilitate their rehabilitation pathway during and after their intensive care unit stay. STUDY

designThis study was conducted as an umbrella review. A systematic search was conducted in CINAHL, Embase, PubMed and PsychINFO, including all types of peer-reviewed research syntheses published between 2008 and 2023. Eligible studies had to describe interventions capable of improving adult patients' cognitive functioning or supporting their cognitive rehabilitation process throughout the intensive care unit trajectory. All eligible research syntheses were screened systematically; those included were critically appraised.

resultBased on 13 research syntheses, this review summarizes rehabilitative interventions that may be delivered during different phases of critical illness and recovery, in relation to content, delivery and timing. Interventions were: (1) cognitive activities and training, (2) mobilization and physical exercises, (3) emotional, psychological and social support and (4) information.

conclusionDue to limited evidence, no definitive conclusion can be drawn about which type of intervention is most supportive or effective. Additionally, no recommendations can be made about the optimal timing for intervention delivery. RELEVANCE TO CLINICAL PRACTICE: Clinicians involved in developing and implementing cognitive rehabilitation measures should consider designing individualized, multicomponent interventions with a focus on content, delivery and timing.

Indexed as

Cognitive DysfunctionCritical IllnessIntensive Care UnitsCognitive TrainingHumansQuality of Lifecognitive impairmentcomplex interventionintensive care unitrehabilitationreview

Identifiers

PMID39503063
PMCPMC12096421

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.