Evidence map›Paper›PMID 39502740›Full record

ArticleNeurology. Genetics2024

Updated Genetic Analysis of Japanese Familial ALS Patients Carrying

Ayumi Nishiyama, Tetsuya Niihori, Naoki Suzuki, Rumiko Izumi, Tetsuya Akiyama, Masaaki Kato, Ryo Funayama, Keiko Nakayama, Hitoshi Warita, Yoko Aoki and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Familial ALS With p. L127S (L126S) Variant of the Cu/Zn SOD1 Gene: A Report of Two New Cases and Literature Review.Neuropathology : official journal of the Japanese Society of Neuropathology · 2025
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ayumi NishiyamaFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-5229-4296
Tetsuya NiihoriFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-2118-9776
Naoki SuzukiFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0001-8880-8554
Rumiko IzumiFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-6701-7814
Tetsuya AkiyamaFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-8076-1242
Masaaki KatoFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0009-0002-5712-009X
Ryo FunayamaFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0009-0008-4983-5566
Keiko NakayamaFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.
Hitoshi WaritaFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0001-7934-3863
Yoko AokiFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0002-1194-6972
Masashi AokiFrom the Departments of Neurology (A.N., N.S., R.I., T.A., M.K., H.W., M.A.), and Medical Genetics (T.N., R.I., Y.A.), Tohoku University School of Medicine; and Division of Cell Proliferation (R.F., K.N.), United Center for Advanced Research and Translational Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan.ORCID https://orcid.org/0000-0001-7284-1069

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Amyotrophic lateral sclerosis (ALS) is an adult-onset progressive neurodegenerative disease. Approximately 10% of ALS cases are familial, and more than 20 causative genes have been identified. As we have previously reported, Methods: We consecutively recruited 160 families with familial ALS in Japan. We performed genetic analyses, focusing on Results: A total of 26 Discussion: The genetic basis of familial ALS, at least for

Identifiers

PMID39502740
PMCPMC11537459

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.