Evidence map›Paper›PMID 39502658›Full record

ArticlemedRxiv : the preprint server for health sciences2024

The role of the microbiota in respiratory virus-bacterial pathobiont relationships in the upper respiratory tract.

Matthew S Kelly, Pixu Shi, Sefelani C Boiditswe, Emily Qin, Andrew P Steenhoff, Tiny Mazhani, Mohamed Z Patel, Coleen K Cunningham, John F Rawls, Kathy Luinstra and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Matthew S KellyBotswana-University of Pennsylvania Partnership, Gaborone, Botswana.ORCID 0000-0001-8819-2315
Pixu ShiDepartment of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States.
Sefelani C BoiditsweBotswana-University of Pennsylvania Partnership, Gaborone, Botswana.
Emily QinDepartment of Biostatistics and Bioinformatics, Duke University, Durham, North Carolina, United States.
Andrew P SteenhoffBotswana-University of Pennsylvania Partnership, Gaborone, Botswana.ORCID 0000-0001-9002-8207
Tiny MazhaniUniversity of Botswana School of Medicine, Gaborone, Botswana.
Mohamed Z PatelUniversity of Botswana School of Medicine, Gaborone, Botswana.
Coleen K CunninghamDivision of Pediatric Infectious Diseases, University of California, Irvine, Children's Hospital of Orange County, Orange, California, United States.
John F RawlsDepartment of Molecular Genetics and Microbiology, Duke University, Durham, North Carolina, United States.ORCID 0000-0002-5976-5206
Kathy LuinstraInfectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.
Jodi GilchristInfectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.
Julia MaciejewskiInfectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.
Jillian H HurstDivision of Pediatric Infectious Diseases, Duke University, Durham, North Carolina, United States.
Patrick C SeedDepartment of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA.
David BulirDepartment of Chemical Engineering, McMaster University, Hamilton, Ontario, Canada.
Marek SmiejaInfectious Disease Research Group, Research Institute of St. Joe's Hamilton, Hamilton, Ontario, Canada.

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Nasopharyngeal Microbiome and Risk of Bacterial Pathogen Colonization in InfantsK23AI135090 · NIAID · DUKE UNIVERSITY · PI KELLY, MATTHEW SCOTT · 2018 to 2022
$860k
Clinical and host microbiome features in the development of acute otitis mediaK01AI173398 · NIAID · DUKE UNIVERSITY · PI Jillian Heyward Hurst · 2023 to 2026
$509k
NIAID NIH HHS K01 AI173398NIAID NIH HHS K23 AI135090NIAID NIH HHS P30 AI045008
6 · The paper itself

Abstract

The mechanisms by which respiratory viruses predispose to secondary bacterial infections remain poorly characterized. Using 2,409 nasopharyngeal swabs from 300 infants in Botswana, we performed a detailed analysis of factors that influence the dynamics of bacterial pathobiont colonization during infancy. We quantify the extent to which viruses increase the acquisition of

Indexed as

childhood respiratory infectionschildrenHaemophilus influenzaeMoraxella catarrhalisnasopharyngeal microbiotarespiratory microbiomeStaphylococcus aureusStreptococcus pneumoniae carriagesub-Saharan Africa

Identifiers

PMID39502658
PMCPMC11537323

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.