Evidence map›Paper›PMID 39502635›Full record

ArticleInternational journal of nanomedicine2024

TME-Activated MnO

Lijuan Chen, Mingbo Liu, Yunjuan Wang, Wei Wei, Yaqiong Li, Yan Bai, Xuan Yu, Lei Jiao, Meiyun Wang

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lijuan Chen *Department of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.ORCID 0000-0002-6761-1338
Mingbo Liu *Department of Radiotherapy, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.
Yunjuan Wang *School of Life Sciences, Henan University, North Section of Jinming Avenue, Kaifeng, Henan, 475004, People's Republic of China.
Wei WeiDepartment of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.
Yaqiong LiDepartment of Pharmacy, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.
Yan BaiDepartment of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.
Xuan YuDepartment of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.
Lei JiaoInstitute of Molecular Metrology, College of Chemistry and Chemical Engineering, Qingdao University, Qingdao, Shandong, 266071, People's Republic of China.
Meiyun WangDepartment of Medical Imaging, Henan Provincial People's Hospital & the People's Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Radiotherapy (RT) is currently recognized as an important treatment for glioblastoma (GBM), however, it is associated with several challenges. One of these challenges is the radioresistance caused by hypoxia, whereas the other is the low conversion efficiency of the strongly oxidized hydroxyl radical (•OH), which is produced by the decomposition of water due to high-energy X-ray radiation. These factors significantly limit the clinical effectiveness of radiotherapy. Results: To address these limitations, we developed a highly stable and efficient nanoplatform (MnO Conclusion: This approach represents a novel and effective strategy for enhancing radiotherapy in gliomas, thereby advancing the field of catalytic radiotherapy and glioma treatment.

Indexed as

Brain NeoplasmsGlioblastomaHydroxyl RadicalMagnetic Resonance ImagingManganese CompoundsOxidesOxygenAnimalsCell Line, TumorHumansMiceMice, Inbred BALB CMice, NudeNanoparticlesPlatinumTumor MicroenvironmentHydroxyl RadicalManganese Compoundsmanganese dioxidemanganese oxideOxidesOxygenPlatinumglioblastomaMnO2/Pt@BSA nanoplatformnanocatalysisradiotherapy

Identifiers

PMID39502635
PMCPMC11537150

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.