Evidence map›Paper›PMID 39502633›Full record

ArticleInternational journal of nanomedicine2024

Iron-Based Nanoplatforms Achieve Hepatocellular Carcinoma Regression Through a Cascade of Effects.

Kunzhao Huang, Xiaoyuan Yi, Huaying Xie, Jianzhang Luo, Qingyu Zeng, Feifei He, Liyan Wang

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kunzhao Huang *Digestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.
Xiaoyuan Yi *Digestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.
Huaying XieDigestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.
Jianzhang LuoDigestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.
Qingyu ZengDigestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.
Feifei HeDigestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.
Liyan WangDigestive Department, The Affiliated Hospital of Guilin Medical College, Guilin, 541001, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Ferroptosis is a regulated form of cell death characterized by iron-dependent accumulation of associated lipid peroxides (LPO), which can induce cell death when a certain level is reached. However, the extremely complex tumor microenvironment (TME) has the characteristics of antioxidant, even if it induces ferroptosis of tumor cells, its killing effect on tumor cells is still very limited. To solve this problem, we constructed a novel nanomaterials (GOx/EC@Fe Methods: We successfully synthesized GOx/EC@Fe Results: The iron-based carriers in GOx/EC@Fe Conclusion: The results showed that the GOx/EC@Fe

Indexed as

Carcinoma, HepatocellularFerroptosisLiver NeoplasmsAnimalsAntineoplastic AgentsCell Line, TumorHep G2 CellsHumansIronMiceMice, Inbred BALB CMice, NudeNF-E2-Related Factor 2Reactive Oxygen SpeciesTumor MicroenvironmentXenograft Model Antitumor AssaysAntineoplastic AgentsIronNF-E2-Related Factor 2Reactive Oxygen Speciesethyl carbamateferroptosisglucose oxidasemesoporous Fe3O4Nrf2

Identifiers

PMID39502633
PMCPMC11537158

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.