Evidence map›Paper›PMID 39502618›Full record

ArticleCancer diagnosis & prognosis

High Subcutaneous Adipose Tissue Radiodensity Predicts Poor Prognosis in Patients With Gastric Cancer.

Shinichiro Iida, Yasunori Matsumoto, Takeshi Toyozumi, Ryota Otsuka, Tadashi Shiraishi, Hiroki Morishita, Tenshi Makiyama, Yuri Nishioka, Masanari Yamada, Atsushi Hirata and 4 more

Abstract read
In one paragraph

Article in Cancer diagnosis & prognosis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Shinichiro IidaDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Yasunori MatsumotoDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Takeshi ToyozumiDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Ryota OtsukaDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Tadashi ShiraishiDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Hiroki MorishitaDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Tenshi MakiyamaDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Yuri NishiokaDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Masanari YamadaDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Atsushi HirataDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Koichi HayanoDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Gaku OhiraDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Masayuki KanoDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.
Hisahiro MatsubaraDepartment of Frontier Surgery, Chiba University Graduate School of Medicine, Chiba, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aim: Although the impact of body composition on cancer treatment outcomes of patients with cancer has been increasingly reported, it is still unclear whether the radiodensity of subcutaneous adipose tissue (SAT) on computed tomography (CT) images has a prognostic impact on patients with gastric cancer. We measured muscle and SAT profiles on CT and performed an integrated analysis with clinicopathologic factors. Patients and Methods: We retrospectively analyzed 230 patients with gastric cancer who underwent gastrectomy between June 2016 and December 2020. SAT radiodensity (SAT-R), and skeletal muscle index (SMI) were measured in preoperative CT images. These were compared with clinicopathologic factors, overall survival (OS), and recurrence-free survival (RFS). Results: High SAT-R was significantly associated with older age (p=0.003) and lower BMI, lymphocyte, hemoglobin, γ-GTP, cholinesterase, albumin, and triglyceride values (p<0.001, <0.001, 0.027, 0.032, <0.001, 0.001, and <0.001, respectively). In the univariate analysis, high SAT-R, and low SMI were significantly associated with poor OS (p=0.003 and <0.001) and poor RFS (p=0.014 and 0.011). In the multivariate analysis by Cox proportional hazard model, high SAT-R and low SMI were identified as independent prognostic factors for poor OS (p=0.037 and 0.007). Conclusion: High SAT-R on preoperative CT was associated with poor OS in patients with gastric cancer after gastrectomy. SAT-R has a potential to be a novel prognostic marker for surgically treated patients with gastric cancer.

Indexed as

Adipose tissue radiodensitygastric cancerskeletal muscle indexsurvival

Identifiers

PMID39502618
PMCPMC11534057

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.