ArticleFrontiers in endocrinology2024
The association between triglyceride-glucose index and gallstones: NHANES 2017-2020.
Article in Frontiers in endocrinology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed.
- Association between albumin-bilirubin score and gallstones: exploring the potential mediating role of body mass index based on NHANES 2017-2020.Internal and emergency medicine · 2026Article
- Association between hepatic steatosis index and gallstones in US adults: A cross-sectional study of NHANES 2017-2020.Medicine · 2026Article
- Article
- Risk stratification for gallstones based on 14 obesity and lipid-related Indices: a longitudinal cohort study of 44,030 Chinese adults.Lipids in health and disease · 2026Article
- Association of the Triglyceride-Glucose Index With Gallstone Disease: A Systematic Review and Meta-Analysis of Observational Studies.JGH open : an open access journal of gastroenterology and hepatology · 2026Review
- The U-shaped association between the metabolic score for insulin resistance and incident gallstone disease: a population-based cohort study.Frontiers in endocrinology · 2026Article
- Non-linear associations of the triglyceride-glucose index with thyroid function in a large Chinese population: a cross-sectional study.Frontiers in nutrition · 2026Article
- Cross-sectional associations of lipid accumulation and immune-nutritional indices with ultrasonography-detected gallstone disease: an explainable machine learning analysis.Frontiers in nutrition · 2026Article
- Exploration of the associations between violent and aggressive behaviors risk and NHHR, TyG in patients with schizophrenia: an SHAP interpretable machine learning prediction and FAERS pharmacovigilance analysis.Lipids in health and disease · 2025Article
- Red blood cell distribution width to albumin ratio as a predictor of gallstones in US adults: a NHANES-based cross-sectional study.Journal of health, population, and nutrition · 2025Article
- Association between various insulin resistance surrogates and gallstone disease based on national health and nutrition examination survey.Scientific reports · 2025Article
- Association between triglyceride-glucose index and intracranial aneurysm rupture: findings from a retrospective study.Neurosurgical review · 2025Observational
- Positive association between cardiometabolic index and gallstones, with greater impact on women and those younger than 50 years: the NHANES 2017-2020 cross-sectional study.BMC public health · 2025Article
- Association between platelet-to-high-density lipoprotein cholesterol ratio and gallstone prevalence in the American adult population: a cross-sectional study analysis.BMC gastroenterology · 2025Article
- Association between fibrosis-4 index (FIB-4) and gallstones: an analysis of the NHANES 2017-2020 cross-sectional study.BMC gastroenterology · 2025Article
- Association between relative fat mass and gallstones: a cross-sectional study based on NHANES 2017-2020.Frontiers in nutrition · 2025Article
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8 authors.
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Abstract
Objects: It remains unclear whether the triglyceride-glucose (TyG) index has correlations with gallstones. This study aimed to investigate the association between TyG index and gallstones. Methods: Data was obtained from the 2017-2020 National Health and Nutrition Examination Survey (NHANES). Participants who provided complete data about TyG index and gallstones were included in the analysis. Multivariable regression analysis and subgroup analysis were preformed to estimate the relationship between TyG index and gallstones. Restricted cubic splines (RSC) was employed to calculate the cut off value. Results: The TyG index was independently associated with gallstones and demonstrates a clear positive correlation (OR = 1.10; 95% CI: 1.01-1.21; p = 0.033). The threshold value is 8.98, showing a positive correlation between TyG index and gallstones when the TyG index is less than 8.98 (Log likelihood ratio P < 0.001). Subgroup analysis indicates that the correlation between TyG and gallstones is mainly observed in individuals with obesity, females, younger individuals, and those with normal blood sugar levels, with these subgroups all acting as mediators between TyG and gallstones. Conclusions: Higher TyG index was linked to a higher chance of developing gallstones. Managing insulin resistance (IR) could help reduce the risk of gallstones since the TyG index is an indicator of IR.
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