Evidence map›Paper›PMID 39502521›Full record

ArticleAnalytical cellular pathology (Amsterdam)2024

Shikonin Induces Autophagy and Apoptosis in Esophageal Cancer EC9706 Cells by Regulating the AMPK/mTOR/ULK Axis.

Junli Zhang, Jiayi Guo, Biao Gu, Fen Wang, Yi Li, Ling Shang, Wendi Jiang, Junrao Ma, Wenjuan Wu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical cellular pathology (Amsterdam), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Junli ZhangBengbu Third People's Hospital Affiliated to Bengbu Medical University, Bengbu 233030, Anhui, China.
Jiayi GuoBengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu 233030, Anhui, China.
Biao GuBengbu Third People's Hospital Affiliated to Bengbu Medical University, Bengbu 233030, Anhui, China.
Fen WangBengbu Third People's Hospital Affiliated to Bengbu Medical University, Bengbu 233030, Anhui, China.
Yi LiBengbu Third People's Hospital Affiliated to Bengbu Medical University, Bengbu 233030, Anhui, China.
Ling ShangBengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu 233030, Anhui, China.
Wendi JiangBengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu 233030, Anhui, China.
Junrao MaBengbu Medical University Key Laboratory of Cancer Research and Clinical Laboratory Diagnosis, Bengbu Medical University, Bengbu 233030, Anhui, China.
Wenjuan WuDepartment of Biochemistry and Molecular Biology, School of Laboratory Medicine, Bengbu Medical University, Bengbu 233030, Anhui, China.ORCID https://orcid.org/0009-0000-8000-6442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Shikonin is a plant medicine extracted from

Indexed as

AMP-Activated Protein KinasesApoptosisAutophagyEsophageal NeoplasmsNaphthoquinonesSignal TransductionTOR Serine-Threonine KinasesAutophagy-Related Protein-1 HomologCell Line, TumorCell MovementCell SurvivalHumansPhosphorylationAMP-Activated Protein KinasesAutophagy-Related Protein-1 HomologMTOR protein, humanNaphthoquinonesshikoninTOR Serine-Threonine Kinasesapoptosisautophagyesophageal cancershikoninthe AMPK/mTOR/ULK axis

Identifiers

PMID39502521
PMCPMC11537739

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.