Prognostic significance of the tumor budding and tumor-infiltrating lymphocytes in survival of hepatocellular carcinoma patients.

Ahmed Mahran Shafiq, Noura Ali Taha, Amen Hamdy Zaky, Abdallah Hedia Mohammed, Ola M Omran, Lobaina Abozaid, Hagir H T Ahmed, Mahmoud Gamal Ameen

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Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Ahmed Mahran ShafiqDepartment of Medical Oncology and Hematological Malignancies, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Noura Ali TahaDepartment of Medical Oncology and Hematological Malignancies, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Amen Hamdy ZakyDepartment of Medical Oncology and Hematological Malignancies, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Abdallah Hedia MohammedDepartment of Medical Oncology and Hematological Malignancies, South Egypt Cancer Institute, Assiut University, Assiut, Egypt.

Ola M OmranDepartment of Pathology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Lobaina AbozaidDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Qassim Region, Saudi Arabia.

Hagir H T AhmedDepartment of Pathology, College of Medicine, Qassim University, Buraidah, Qassim Region, Saudi Arabia.

Mahmoud Gamal AmeenDepartment of Oncologic Pathology, South Egypt Cancer Institute, Assiut University, Assiut Egypt.

Funding

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6 · The paper itself

Abstract

Objective: In spite of great advance in the management of hepatocellular carcinoma (HCC), the prognostic factors are still obviously not understood. The role of tumor budding (TB) and tumor-infiltrating lymphocytes (TILs) in HCC as pathological parameters affecting prognosis stands principally unknown. Methods: Seventy-four surgical resection pathology specimens of HCC patients were used. Assessment of TB and TILs were performed using hematoxylin-eosin-stained slides. Follow-up data were collected over a 5-year period to determine disease-free survival rates, overall survival (OS) rates, and how they related to TB, TILs, and other clinicopathological factors. Results: There was a significant statistical association between high-grade TB and lymphovascular embolization (LVE), tumor necrosis, and grade of HCC with Conclusions: In all HCC patients, TB was seen, and there was a significant link between the grade of the HCC and the presence of tumor necrosis, LVE, and high-grade TB. The majority (92%) of HCC patients had TILs, and there was a strong relationship between the histological grade, LVE, and serum AFP level. While TILs show variation of the immunologic reaction to the tumor, TB tends to suggest a hostile biologic nature and a bad prognosis.

Indexed as

Hepatocellular carcinomaoverall survivaltumor buddingtumor-infiltrating lymphocytes

Identifiers

PMID39502429

PMCPMC11533185

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