ArticleInternational journal of health sciences
Design and synthesis of a novel isoleucine-derived Schiff base ligand: Structural characterization, molecular docking, and
Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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Who cites it
3 citing papers in PubMed.
- Antifungal Activity and Possible Mechanism of Action of the Zn (II) Complex With a Schiff Base Against Fluconazole-Resistant Strains of Candida spp. and Cryptococcus neoformans.Chemistry & biodiversity · 2026Article
- Anticancer Activity of Schiff Base Metal Complexes Against MCF-7 Breast Cancer Cell Line.International journal of molecular sciences · 2026Review
- Synthesis, computational, biological activity and molecular docking study of CoScientific reports · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Schiff bases are versatile chemical compounds extensively used in various applications, including as catalysts, polymer stabilizers, pigments, dyes, and building blocks for organic synthesis. In addition, they exhibit a wide range of biological activities, such as antifungal, antibacterial, antiviral, antiproliferative, anti-inflammatory, and antipyretic effects. Methods: A novel Schiff base ligand (HL) was synthesized by condensing isatin with 2,6-diaminopyridine and isoleucine, followed by the preparation of transition metal complexes. The ligand and complexes were characterized using techniques such as elemental analysis, IR, 1H-NMR, UV-vis spectroscopy, mass spectrometry, and thermal analysis. Antimicrobial, antiproliferative activities, and structural investigations through X-ray diffraction and scanning electron microscopy were also evaluated. Results: The complexes were identified as [Cr(L)Cl(H Conclusion: These newly synthesized ligands and complexes show promise as therapeutic agents against infections and cancer, though further studies are needed to understand their mechanisms.
Indexed as
Identifiers
39502428PMC11533187What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.