ArticleClinical kidney journal2024
Immunosuppression and transplantation-related characteristics affect the difference between eGFR equations based on creatinine compared to cystatin C in kidney transplant recipients.
Article in Clinical kidney journal, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Medications Influencing Serum Cystatin C Independent of Measured GFR.Journal of the American Society of Nephrology : JASN · 2026Article
- Impact of Estimated Glomerular Filtration Rate Equations on Vancomycin Dosing and Treatment Outcomes.Drug design, development and therapy · 2026Article
- The Patient and Treatment Characteristics of Kidney Transplant Recipients with a Clinically Relevant Jaffe/Enzymatic Serum Creatinine Difference.Journal of clinical medicine · 2025Article
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7 authors.
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Abstract
Introduction: Previous studies show heterogeneity when applying estimated glomerular filtration (eGFR) equations to kidney transplant recipients (KTRs). However, research on the impact of transplantation-related characteristics on eGFR equations using creatinine (eGFRcr) compared to cystatin C (eGFRcys) is scarce. Methods: We conducted a comprehensive analysis with three eGFRcr equations (Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) 2009, European Kidney Function Consortium (EKFC) 2021, kidney recipient specific-glomerular filtration rate KRS-GFR) 2023), comparing them to two eGFRcys (CKD-EPI 2012 and EKFC 2023) in 596 KTRs. Bland-Altman plots demonstrated relative differences according to different eGFR-stages. Multivariable logistic regression identified transplantation-related characteristics independently associated with smaller or greater differences between eGFRcr and eGFRcys equations. Results: 94.3% of the cohort were White individuals. Median eGFR differed as much as 9 ml/min/1.73 m Conclusion: Different eGFR-stages, donor, or recipient characteristics, along with immunosuppression such as belatacept or prednisone, contribute to differences between eGFRcr and eGFRcys. These effects need to be considered in the clinical management of KTRs.
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