Evidence map›Paper›PMID 39502292›Full record

ArticleiScience2024

Mycobacteria develop biofilms on airway epithelial cells and promote mucosal barrier disruption.

Amy M Barclay, Dennis K Ninaber, Ronald W A L Limpens, Kimberley V Walburg, Montserrat Bárcena, Pieter S Hiemstra, Tom H M Ottenhoff, Anne M van der Does, Simone A Joosten

Abstract read
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Article
  3. Critical reviews in microbiology · 2026
    Review
  4. Cell wall remodeling-dependent morphotype switch inProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Review
  6. Biofilm Associated Persistence and Drug Tolerance in Mycobacteria Within Host Microenvironments.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2026
    Review
  7. Article
  8. Article
  9. Current topics in medicinal chemistry · 2026
    Article
  10. Review
  11. Article
  12. An alveolus lung-on-a-chip model ofbioRxiv : the preprint server for biology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amy M BarclayLeiden University Center for Infectious Diseases, (LUCID), Leiden University Medical Center, Leiden, the Netherlands.
Dennis K NinaberPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
Ronald W A L LimpensDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Kimberley V WalburgLeiden University Center for Infectious Diseases, (LUCID), Leiden University Medical Center, Leiden, the Netherlands.
Montserrat BárcenaDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, the Netherlands.
Pieter S HiemstraPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
Tom H M OttenhoffLeiden University Center for Infectious Diseases, (LUCID), Leiden University Medical Center, Leiden, the Netherlands.
Anne M van der DoesPulmoScience Lab, Department of Pulmonology, Leiden University Medical Center, Leiden, the Netherlands.
Simone A JoostenLeiden University Center for Infectious Diseases, (LUCID), Leiden University Medical Center, Leiden, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tuberculosis displays several features commonly linked to biofilm-associated infections, including recurrence of infection and resistance to antibiotic treatment. The respiratory epithelium represents the first line of defense against pathogens such as

Indexed as

BacteriologyClinical microbiologyMedical microbiologyMicrobiology

Identifiers

PMID39502292
PMCPMC11536035

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.