Evidence map›Paper›PMID 39502256›Full record

ArticleHeliyon2024

Anti-LGI1 encephalitis and Langerhans cell histiocytosis: Two associated entities? A case report.

Denise Cerne, Federico Massa, Marco Mora, Silvia Morbelli, Luca Roccatagliata, Giacomo Rebella, Flavio Villani, Federica Bozzano, Antonio Uccelli, Luana Benedetti and 1 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Denise CerneDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Federico MassaDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Marco MoraU.O. Anatomia Patologica Ospedaliera, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy.
Silvia MorbelliDepartment of Medical Sciences, University of Turin, Italy.
Luca RoccatagliataDepartment of Health Sciences (DISSAL), University of Genoa, Genoa, Italy.
Giacomo RebellaNeuroradiology Unit, IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Flavio VillaniDivision of Neurophysiology and Epilepsy Centre, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Federica BozzanoAutoimmunity Laboratory, IRCCS Ospedale Policlinico San Martino, Genova, Italy.
Antonio UccelliDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Genoa, Italy.
Luana BenedettiIRCCS, Ospedale Policlinico San Martino, Genoa, Italy.
Corrado CabonaDivision of Neurophysiology and Epilepsy Centre, IRCCS Ospedale Policlinico San Martino, Genova, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autoimmune encephalitis (AE) is an immune-mediated condition that induces brain inflammation due to several neural-specific autoantibodies. The main triggering and predisposing factors are infections, genetics, the use of immune checkpoint inhibitors and tumors. We report a case of a 57-year-old male with a biopsy-confirmed Langerhans cell histiocytosis (LCH) and a concomitant anti-LGI1 encephalitis discussing a possible relationship in the pathogenesis of these phenomena. Only sporadic cases of AE developing in the context of histiocytic neoplasms have been described and there are no other reports on the relationship between LGI1-AE and LCH worldwide due to small number of cases.

Indexed as

Case reportIL-6Langerhans cell histiocytosisLGI1 encephalitisParaneoplastic

Identifiers

PMID39502256
PMCPMC11535343

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.