Evidence map›Paper›PMID 39502172›Full record

ArticleFrontiers in cellular and infection microbiology2024

Novel antimicrobial coating for hernia meshes.

Klaus Dieter Kühn, Débora C Coraça-Huber, Michael Erdtmann, Gerwin A Bernhardt, Christian Fölsch

Abstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Klaus Dieter KühnDepartment of Orthopaedics and Trauma, Medical University Graz, Graz, Austria.
Débora C Coraça-HuberExperimental Orthopaedics, Medical University Innsbruck, Innsbruck, Austria.
Michael ErdtmannQC Department, Hemoteq AG, Würselen, Germany.
Gerwin A BernhardtDivision of General Surgery, Department of Surgery, University of Graz, Graz, Austria.
Christian FölschDepartment of Orthopaedic Surgery, Universitätsklinikum Gießen und Marburg (UKGM), Justus-Liebig-University, Gießen, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Antibiotic coating for several medical devices has been carried out; however, there are only few studies about coating hernia meshes with antimicrobial substances. In this study we checked the capacity of different commercially available hernia meshes to act as drug carrier. Methods: The meshes were coated with gentamicin palmitate, chlorhexidine palmitic acid and chlorhexidine palmitate. The coating mass and subsequent Results: 1. Certain uniformity was observed on the quantity of chlorhexidine coating the surface of each mesh used when compared with gentamicin palmitate coating. 2.We did not detect significant difference between the amounts of gentamicin palmitate released from each mesh. 3. The release of chlorhexidine palmitate and chlorhexidine palmitic acid from UltraPro™ and Mersilene™ were significantly higher (p<0.05) in comparison with the other two meshes. 4. The coating substances covered the surface of the fibers without damaging its structure. 5. The coating substances were distributed all along the fibers in all samples. Conclusions: We suggest the use of chlorhexidine palmitate and chlorhexidine palmitic acid, as well as gentamicin palmitate, for coating of hernia meshes aiming prevention of infections. Further investigation of the bactericidal effect of coated hernia meshes against biofilm form of

Indexed as

ChlorhexidineCoated Materials, BiocompatibleGentamicinsSurgical MeshAnti-Bacterial AgentsAnti-Infective AgentsDrug CarriersHumansMicroscopy, Electron, ScanningPalmitic AcidAnti-Bacterial AgentsAnti-Infective AgentsChlorhexidineCoated Materials, BiocompatibleDrug CarriersGentamicinsPalmitic Acidbiofilmchlorhexidine palmitatechlorhexidine palmitic acidgentamicin palmitatehernia meshesinfection

Identifiers

PMID39502172
PMCPMC11534812

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.