Evidence map›Paper›PMID 39502084›Full record

ArticleCornea open2024

Multimodal Imaging of Posterior Corneal Opacities in Multicentric Osteolysis Nodulosis and Arthropathy (MONA).

Sarah E Eppley, Neel D Pasricha, Gerami D Seitzman, Ashlin Joye, Alejandro Arboleda, Azam Qureshi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cornea open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sarah E EppleyDepartment of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA.
Neel D PasrichaDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Gerami D SeitzmanDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Ashlin JoyeDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Alejandro ArboledaDepartment of Ophthalmology, University of California, San Francisco, San Francisco, CA, USA.
Azam QureshiDepartment of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA.

Funding

Rapid-Prototyping and Design CoreP30EY002162 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAMBA, DEEPAK ASHOK · 1985 to 2024
$16.8M
UCSF-Proctor Clinician Vision Scholars K12 ProgramK12EY031372 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THOMAS M LIETMAN, Yvonne Ou · 2020 to 2026
$3.9M
Human Ocular Surface ElectrophysiologyK08EY033859 · NEI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Neel Dave Pasricha · 2023 to 2026
$877k
NEI NIH HHS K08 EY033859NEI NIH HHS K12 EY031372NEI NIH HHS P30 EY002162
6 · The paper itself

Abstract

Purpose: Multicentric osteolysis nodulosis and arthropathy (MONA) syndrome is a rare autosomal recessive skeletal dysplasia. Caused by mutations in the matrix metalloproteinase 2 gene ( Methods: Complete ophthalmologic examination and multimodal anterior segment imaging were used to characterize the corneal findings in a patient with MONA syndrome. Results: A 19-year-old with MONA syndrome was referred for an eye exam based upon MONA screening recommendations. Visually insignificant peripheral corneal opacities were noted. Anterior segment optical coherence tomography (AS-OCT) demonstrated posterior stromal and endothelial hyperreflectivity. Confocal microscopy demonstrated an acellular peripheral endothelium with a normal central endothelium. Conclusions: Corneal opacities can occur with MONA syndrome, which is caused by mutations in the

Indexed as

collagenasecorneal opacitygelatinasematrix metalloproteinase 2multicentric osteolysis nodulosis and arthropathy

Identifiers

PMID39502084
PMCPMC11537491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.