Evidence map›Paper›PMID 39501912›Full record

ArticleEuropean journal of haematology2025

Risk of Cardiovascular Disease in Patients With Classical Hodgkin Lymphoma: A Danish Nationwide Register-Based Cohort Study.

Sissel J Godtfredsen, Harman Yonis, Joachim Baech, Nour R Al-Hussainy, Signe Riddersholm, Lars Kober, Morten Schou, Jacob Haaber Christensen, Martin Hutchings, Rasmus Bo Dahl-Sørensen and 7 more

Abstract read
In one paragraph

Article in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Caught in the crossfire: cardiac complications of cancer therapy.The Journal of clinical investigation · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Sissel J GodtfredsenDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.ORCID https://orcid.org/0000-0002-1049-9285
Harman YonisDepartment of Cardiology, Nordsjaellands Hospital, Hillerod, Denmark.
Joachim BaechDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Nour R Al-HussainyDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Signe RiddersholmDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Lars KoberDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Morten SchouDepartment of Cardiology, Copenhagen University Hospital - Herlev and Gentofte Hospital, Hellerup, Denmark.
Jacob Haaber ChristensenDepartment of Hematology, Odense University Hospital, Odense, Denmark.
Martin HutchingsDepartment of Hematology, Copenhagen University Hospital, Copenhagen, Denmark.
Rasmus Bo Dahl-SørensenDepartment of Hematology, Zealand University Hospital, Roskilde, Denmark.
Peter KamperDepartment of Hematology, Aarhus University Hospital, Aarhus, Denmark.
Caroline E DietrichDepartment of Medicine Solna, Clinical Epidemiology Division, Karolinska Institutet, Stockholm, Sweden.
Mikkel Porsborg AndersenDepartment of Cardiology, Nordsjaellands Hospital, Hillerod, Denmark.
Christian Torp-PedersenDepartment of Cardiology, Nordsjaellands Hospital, Hillerod, Denmark.
Peter SogaardDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Tarec Christoffer El-GalalyDepartment of Hematology, Clinical Cancer Research Center, Aalborg University Hospital, Aalborg, Denmark.
Kristian H KragholmDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.

Funding

Aalborg UniversitetshospitalKræftens bekæmpelse R327-A18892
6 · The paper itself

Abstract

Risk of cardiovascular disease (CVD) in patients with classical Hodgkin lymphoma (cHL) undergoing contemporary treatment is unclear. cHL patients ≥ 18 years at diagnosis treated with doxorubicin-containing chemotherapy between 2000 and 2022 were matched 1:5 with comparators on birth year, sex, and Charlson Comorbidity Index at time of matching (score of 0 or ≥ 1). Cause-specific cumulative incidence of a composite of CVDs with corresponding 95% confidence intervals (CIs) were computed with death and lymphoma relapse as competing events (i.e., by censoring individuals at such occurrences) using the Aalen-Johansen estimator. A total of 1905 patients and 9525 comparators with a median follow-up of 10 years (interquartile range, [IQR]: 5.9-17.4). Median age was 39 years (IQR: 27-56), median cumulative doxorubicin dose was 250 mg/m

Indexed as

Cardiovascular DiseasesHodgkin DiseaseRegistriesAdultAgedAntineoplastic Combined Chemotherapy ProtocolsCohort StudiesComorbidityDenmarkDoxorubicinFemaleHumansIncidenceMaleMiddle AgedRisk FactorsDoxorubicincardiotoxicityHodgkin lymphomalate effects of treatment

Identifiers

PMID39501912
PMCPMC11707824

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.