Evidence map›Paper›PMID 39501720›Full record

ArticleThe Journal of international medical research2024

Sjögren's syndrome positive for isolated anti-Ro52/SS-A antibody and anti-centromere antibody.

Hideki Nakamura, Masako Tsukamoto, Kinya Nagata, Yosuke Nagasawa, Kumiko Akiya, Hirotake Inomata, Masahiro Nishihara, Shin-Ya Asatani, Noboru Kitamura, Hisataka Kitano and 4 more

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Hideki NakamuraDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.ORCID 0000-0002-5837-6348
Masako TsukamotoDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Kinya NagataDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Yosuke NagasawaDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Kumiko AkiyaDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Hirotake InomataDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Masahiro NishiharaDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Shin-Ya AsataniDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Noboru KitamuraDivision of Haematology and Rheumatology, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.ORCID 0000-0002-8454-988X
Hisataka KitanoDivision of Oral and Maxillofacial Surgery, Department of Medicine, Nihon University School of Medicine, Tokyo, Japan.
Jun ShojiDivision of Ophthalmology, Department of Visual Sciences, Nihon University School of Medicine, Tokyo, Japan.
Yu IwabuchiDepartment of Radiology, Keio University School of Medicine, Tokyo, Japan.
Toshiyuki IshigeDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.
Hiroyuki HaoDivision of Human Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This current case report describes a Japanese woman in her 80s with xerostomia who presented with salivary gland dysfunction. She was positive for isolated anti-Ro52/SS-A antibody as determined by a chemiluminescent enzyme immunoassay and positive on a fluorescence enzyme immunoassay that recognizes both Ro52 and Ro60 antigens. A high serum concentration of anti-Ro52/SS-A antibody was determined by an enzyme-linked immunosorbent assay. A high anti-centromere antibodies (ACA) titre was also observed. Although Raynaud's phenomenon or a high serum immunoglobulin G concentration were not observed, Masson-trichrome staining of the patient's labial salivary glands showed considerable fibrosis. Her serum type I and type II interferon concentrations were normal. The present patient is the first with Sjögren's syndrome (SS) to exhibit isolated anti-Ro52/SS-A antibody and ACA without anti-Ro60/SS-A antibody. This current case report presents her case together with those of four other SS patients who were positive for isolated anti-Ro52/SS-A antibody. The SS literature also includes cases positive for ACA and describes clinical characteristics. The other four SS patients with isolated anti-Ro52/SS-A antibody described here had no ACA; interstitial pneumonia and polyneuropathy were observed in these cases, although there was no consistent tendency regarding types I and II interferon.

Indexed as

Antibodies, AntinuclearRibonucleoproteinsSjogren's SyndromeAged, 80 and overAutoantibodiesCentromereFemaleHumansSS-A AntigenAntibodies, AntinuclearAutoantibodiesRibonucleoproteinsSS-A antibodiesSS-A Antigenanti-centromere antibodyAnti-Ro52/SS-A antibodyinterferon-αSjögren’s syndrome

Identifiers

PMID39501720
PMCPMC11539262

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.