Trial reportMedicine and science in sports and exercise2025
Ingestion of a Whey Plus Collagen Protein Blend Increases Myofibrillar and Muscle Connective Protein Synthesis Rates.
Trial report in Medicine and science in sports and exercise, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The potential effect of whey protein supplementation in post-bariatric surgery patients: a systematic review and meta-analysis of randomized controlled trials.Frontiers in nutrition · 2026Pooled it
- The impact of tangeretin combined with whey protein supplementation on body composition and hormonal profiles in elite sprinters: A double-blind RCT.Journal of exercise science and fitness · 2026Article
- Mechanistic interactions of diet, exercise, and pharmacotherapy in skeletal muscle metabolism: evidence and translational perspectives.Frontiers in physiology · 2026Review
- A collagen amino acid composition supplementation reduces biological age in humans and increases health and lifespan in vivo.npj aging · 2025Article
- Current Perspectives on Protein Supplementation in Athletes: General Guidance and Special Considerations for Diabetes-A Narrative Review.Nutrients · 2025Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIngestion of whey protein increases myofibrillar but not muscle connective protein synthesis rates. Recently, we defined a whey and collagen protein blend (5:1 ratio) to optimize post-prandial plasma amino acid availability. Here, we assessed the ability of this blend to increase myofibrillar and muscle connective protein synthesis rates at rest and during early recovery from exercise.
methodsIn a randomized, double-blind, parallel design, 28 men (age: 25 ± 5 yr; body mass index: 23.6 ± 2.3 kg·m -2 ) were randomly allocated to ingest either 30 g of protein (25 g whey/5 g collagen; BLEND, n = 14) or a noncaloric placebo (PLA, n = 14) following a single session of unilateral leg resistance-type exercise. Participants received primed continuous l -[ ring - 13 C 6 ]-phenylalanine infusions with blood and muscle biopsy samples collection for 5 h post-prandially to assess myofibrillar and muscle connective protein synthesis rates.
resultsProtein ingestion strongly increased plasma amino acid concentrations, including plasma leucine and glycine concentrations ( P < 0.001), with no changes following placebo ingestion ( P > 0.05). Post-prandial myofibrillar and muscle connective protein synthesis rates were higher in the exercised compared with the rested leg ( P < 0.001). In addition, myofibrillar protein synthesis rates were higher in BLEND compared with PLA in both the rested (0.038 ± 0.008 and 0.031 ± 0.006%·h -1 , respectively; P < 0.05) and exercised (0.052 ± 0.011 and 0.039 ± 0.009%·h -1 , respectively; P < 0.01) leg. Muscle connective protein synthesis rates were higher in BLEND compared with PLA in the rested (0.062 ± 0.013 and 0.051 ± 0.010%·h -1 , respectively; P < 0.05), but not the exercised (0.090 ± 0.021 and 0.079 ± 0.016%·h -1 , respectively; P = 0.11) leg.
conclusionsIngestion of a whey (25 g) plus collagen (5 g) protein blend increases both myofibrillar and muscle connective protein synthesis rates at rest and further increases myofibrillar but not muscle connective protein synthesis rates during recovery from exercise in recreationally active, young men.
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