Evidence map›Paper›PMID 39501168›Full record

ArticleGut microbes

Giardia antagonizes beneficial functions of indigenous and therapeutic intestinal bacteria during protein deficiency.

Aadra P Bhatt, Jason W Arnold, Muyiwa Awoniyi, Shan Sun, Verônica Feijoli Santiago, Deniz Coskuner, Pedro Henrique Quintela, Kenneth Walsh, Jamie Xiao, Renay Ngobeni-Nyambi and 7 more

Abstract read
In one paragraph

Article in Gut microbes. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. New combination therapy of praziquantel andFood and waterborne parasitology · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Aadra P BhattDivision of Gastroenterology and Hepatology, Department of Medicine, and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-0134-6543
Jason W ArnoldDepartment of Molecular Genetics and Microbiology, Duke Microbiome Center, Duke University School of Medicine, Durham, North Carolina, USA.ORCID 0000-0002-6363-6140
Muyiwa AwoniyiDepartment of Gastroenterology Hepatology and Nutrition, Digestive Diseases and Surgery Institute of the Cleveland Clinic Foundation, and Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA.ORCID 0000-0002-5811-070X
Shan SunDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Verônica Feijoli SantiagoSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-0052-9532
Deniz CoskunerCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Pedro Henrique QuintelaInstitute of Biomedicine, Federal University of Ceará, Fortaleza, CE, Brazil.
Kenneth WalshDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Jamie XiaoDivision of Infectious Diseases, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Renay Ngobeni-NyambiDepartment of Microbiology, Stellenbosch University, Stellenbosch, South Africa.ORCID 0000-0001-9235-1542
Brenna HansenDepartment of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Ajay S GulatiCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7612-6369
Ian M CarrollDepartment of Nutrition, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
M Andrea Azcarate-PerilCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0325-1289
Anthony A FodorDepartment of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, USA.
Jonathan SwannSchool of Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK.ORCID 0000-0002-6485-4529
Luther A BarteltCenter for Gastrointestinal Biology and Disease, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0002-7596-4272

Funding

UNIV OF NORTH CAROLINA CLINICAL NUTRITION RESEARCH UNITP30DK056350 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Venkata Saroja Voruganti · 1999 to 2026
$31.6M
PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ROBERT S. SANDLER · 1985 to 2026
$30.5M
Interactions of dietary protein intake and intestinal resident microbiota affecting susceptibility to persistent Giardia infection and Giardia mediated enteropathyR01AI151214 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BARTELT, LUTHER A · 2020 to 2024
$3.1M
NIAID NIH HHS R01 AI151214NIDDK NIH HHS P30 DK034987NIDDK NIH HHS P30 DK056350
6 · The paper itself

Abstract

Undernutrition in children commonly disrupts the structure and function of the small intestinal microbial community, leading to enteropathies, compromised metabolic health, and impaired growth and development. The mechanisms by which diet and microbes mediate the balance between commensal and pathogenic intestinal flora remain elusive. In a murine model of undernutrition, we investigated the direct interactions

Indexed as

Bile Acids and SaltsGastrointestinal MicrobiomeGiardiasisLactobacillusProtein DeficiencyAnimalsBifidobacteriumDisease Models, AnimalFemaleGiardiaGiardia lambliaHumansIntestinal MucosaMaleMiceMice, Inbred C57BLBile Acids and Saltsbile acidsGiardiagnotobiotic modelsmalnourishmentprobiotics

Identifiers

PMID39501168
PMCPMC11542603

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.