ArticleNature genetics2024
Structural variation reshapes population gene expression and trait variation in 2,105 Brassica napus accessions.
Article in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research evolution of flat peach (Frontiers in plant science · 2025Pooled it
- Uncovering structural variation in conifer gigagenomes: evolutionary insights and technical challenges.Molecular biology and evolution · 2026Article
- Genome-wide variation analysis of two Salvia hispanica L. genotypes and implication for associations with metabolic and adaptive traits.Journal, genetic engineering & biotechnology · 2026Article
- Haplotype-resolved genome assembly of femaleHorticulture research · 2026Article
- The Rise of Plant Pan-Genomes: From Genome Variation to Predictive Breeding.Advanced genetics (Hoboken, N.J.) · 2026Article
- Regulatory divergence of homoeologs underlies network optimization for fiber improvement in domesticated cotton.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Structural Variation and Its Roles in Plant Genomes.Plants (Basel, Switzerland) · 2026Review
- A deep learning model captures position-specific effects of plant regulatory sequences and suggests genes under complex regulation.Plant physiology · 2026Article
- Comparative genomics and time-course transcriptomics uncover homoeologous exchange events reshaping glucosinolate metabolism in Brassica napus.Molecular horticulture · 2026Article
- A dual genome-methylome map of clonal evolution in grapevine.Genome biology · 2026Article
- Chromosomal collinearity drives meiotic instability in Brassica autoallopolyploid.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026Article
- T2T reference genome assembly provides insights into anthocyanin accumulation in broccoli.Horticulture research · 2026Article
- Functional divergence of BnaWRKY7 homologs drives phytosterol variations in polyploid Brassica napus.Journal of advanced research · 2026Article
- Genome-wide identification of NRAMP gene family in Brassica U's triangle species and its response to Cadmium stress in B. napus.BMC plant biology · 2026Article
- Structural Genomic Variation and Its Potential Role in Deer Speciation.Molecular ecology · 2026Article
- Chromosome-level genome and population resequencing reveal genetic diversity, demographic history, and climate risk in the East Asian relict treePlant diversity · 2026Article
- Haploid Mutation Mapping Identifies a Homoeologous Non-Reciprocal Translocation Linked to Reduced Fibre and Enhanced Protein in Brassica napus.Plant biotechnology journal · 2026Article
- Glucosinolates inInternational journal of molecular sciences · 2026Review
- The pangenome ofiScience · 2026Article
- Genome-Wide Identification and Evolutionary Analysis of Sucrose Synthase (Plants (Basel, Switzerland) · 2026Article
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Authors and funding
18 authors.
Funding
Abstract
Although individual genomic structural variants (SVs) are known to influence gene expression and trait variation, the extent and scale of SV impact across a species remain unknown. In the present study, we constructed a reference library of 334,461 SVs from genome assemblies of 16 representative morphotypes of neopolyploid Brassica napus accessions and detected 258,865 SVs in 2,105 resequenced genomes. Coupling with 5 tissue population transcriptomes, we uncovered 285,976 SV-expression quantitative trait loci (eQTLs) that associate with altered expression of 73,580 genes. We developed a pipeline for the high-throughput joint analyses of SV-genome-wide association studies (SV-GWASs) and transcriptome-wide association studies of phenomic data, eQTLs and eQTL-GWAS colocalization, and identified 726 SV-gene expression-trait variation associations, some of which were verified by transgenics. The pervasive SV impact on how SV reshapes trait variation was demonstrated with the glucosinolate biosynthesis and transport pathway. The study highlighting the impact of genome-wide and species-scale SVs provides a powerful methodological strategy and valuable resources for studying evolution, gene discovery and breeding.
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