ReviewNature genetics2024
A history of multiple Denisovan introgression events in modern humans.
Review in Nature genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The global prevalence of horizontal strabismus: A systematic review and meta-analysis with a focus on ethnic variation.Survey of ophthalmologyPooled it
- Article
- Article
- Archaic ancestry inference in imputed ancient human genomes.Nature communications · 2026Article
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- The evolutionary origin of the collective unconscious and the appeal of research on Neanderthals and other ancient humans.Frontiers in psychology · 2026Article
- The Interpupillary Distance Differs Between Ethnicities and Associates with Horizontal Strabismus Patterns: Evidence from a Systematic Review and Meta-Analysis.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- The interpupillary distance differs between ethnicities and associates with horizontal strabismus patterns: Evidence from a systematic review and meta-analysis.medRxiv : the preprint server for health sciences · 2025Article
- The global prevalence of horizontal strabismus: a systematic review and meta-analysis with a focus on ethnic variation.medRxiv : the preprint server for health sciences · 2025Article
- Ancient genomes give insight into 160,000 years of East Asian population dynamics and biological adaptation.Genome biology · 2025Review
- Association of Chromosome 3p21.32 Haplotype Blocks Introgressed from Neanderthals with Critical COVID-19 in a Spanish Cohort.Life (Basel, Switzerland) · 2025Article
- TheScience (New York, N.Y.) · 2025Article
- Population histories of the Indigenous Adivasi and Sinhalese from Sri Lanka using whole genomes.Current biology : CB · 2025Article
- Functional analysis of CYP4B1 enzymes from apes and humans uncovers evolutionary hot spots for adaptations of the catalytical function.PLoS genetics · 2025Article
- Refinement of Poultry Standing in Japan Based on Recent Anthropo-ornithological Perspectives.The journal of poultry science · 2025Review
- Becoming human in the age of AI: cognitive co-evolutionary processes.Frontiers in psychology · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The identification of a new hominin group in the Altai mountains called Denisovans was one of the most exciting discoveries in human evolution in the last decade. Unlike Neanderthal remains, the Denisovan fossil record consists of only a finger bone, jawbone, teeth and skull fragments. Leveraging the surviving Denisovan segments in modern human genomes has uncovered evidence of at least three introgression events from distinct Denisovan populations into modern humans in the past. Each of them presents different levels of relatedness to the sequenced Altai Denisovan, indicating a complex relationship between these sister lineages. Here we review the evidence suggesting that several Denisovan populations, who likely had an extensive geographical range, were adapted to distinct environments and introgressed into modern humans multiple times. We further discuss how archaic variants have been affected by demographic history, negative and positive selection and close by proposing possible new lines of future research.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.