Evidence map›Paper›PMID 39500972›Full record

ArticleScientific reports2024

Enhanced auditory responses in visual cortex of blind rats using intrinsic optical signal imaging.

Shu Maruoka, Eriko Sugano, Ryunosuke Togawa, Norihiro Katayama, Kitako Tabata, Naoto Yoshizawa, Ryohei Morita, Yuya Takita, Taku Ozaki, Tomokazu Fukuda and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Shu Maruoka *Laboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Eriko Sugano *Laboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Ryunosuke TogawaKDDI Research, Inc, 2-1-15 Ohara, Fujimino Saitama, 356-8502, Japan.
Norihiro KatayamaFaculty of Science and Engineering, Shokei Gakuin University, 4-10-4 Yurigaoka, Natori, Miyagi, 981-1295, Japan.
Kitako TabataLaboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Naoto YoshizawaLaboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Ryohei MoritaLaboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Yuya TakitaLaboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Taku OzakiGraduate Course in Biological Sciences, Division of Science and Engineering, Iwate University, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Tomokazu FukudaGraduate Course in Biological Sciences, Division of Science and Engineering, Iwate University, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Lanlan BaiGraduate Course in Biological Sciences, Division of Science and Engineering, Iwate University, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan.
Hiroshi TomitaLaboratory of Visual Neuroscience, Graduate Course in Biological Sciences, Iwate University Division of Science and Engineering, 4-3-5 Ueda, Morioka Iwate, 020-8551, Japan. htomita@iwate-u.ac.jp.

Funding

Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology in Japan 22H00579, 21K18278, 22K09760, 21K09713Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology in Japan JP22H04922 [AdAMS]Terumo Foundation for Life Sciences and Arts 21-II4001
6 · The paper itself

Abstract

Functional maturation of the visual cortex is induced by visual experiences during critical periods. Blind animals and humans exhibit improved auditory abilities after losing their vision. Here we investigated the response of the visual cortex to white noise stimuli during the progression of photoreceptor degeneration in a rat model of blindness (Royal College of Surgeons [RCS] (rdy/rdy) rats). Optical coherence tomography of RCS (+/+) rats with normal visual function revealed normal photoreceptor cells, whereas 3-month-old RCS (rdy/rdy) rats demonstrated photoreceptor cell degeneration. Visual cortex responses (VCRs) to a single flash stimulus were negligible in 3-month-old photoreceptor-degenerated rats. However, VCRs with white noise stimuli were significantly increased in blind versus RCS rats (+/+). Slight changes in the intrinsic optical signals of the control rats were observed on the ventral side of the visual cortex. In contrast, responses were markedly increased throughout the visual cortex of RCS (rdy/rdy) rats. These results indicate that the visual cortex rapidly acquires auditory system function over the first 3 months of life and that the entire visual cortex, rather than just the portion close to the auditory cortex, responds to white noise.

Indexed as

Auditory CortexBlindnessVisual CortexAcoustic StimulationAnimalsDisease Models, AnimalMaleOptical ImagingRatsRetinal DegenerationTomography, Optical CoherenceAuditory responseBlindnessIntrinsic optical signal imagingVisual cortexVisual evoked potential

Identifiers

PMID39500972
PMCPMC11538334

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.