Evidence map›Paper›PMID 39500850›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Menstrual Blood-Derived Endometrial Stem Cells Ameliorate Ovarian Senescence by Relieving Oxidative Stress-Induced Inflammation.

Haofeng Song, Ruiyun Zhang, Yinglei Liu, Jie Wu, Wenqiang Fan, Junfang Wu, Yanli Liu, Juntang Lin

Abstract read
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In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haofeng SongStem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Xinxiang Medical University, No. 601 East JinSui Road, Xinxiang, 453003, Henan Province, China.
Ruiyun ZhangStem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Xinxiang Medical University, No. 601 East JinSui Road, Xinxiang, 453003, Henan Province, China.
Yinglei LiuHenan Joint International Research Laboratory of Stem Cell Medicine, School of Biomedical Engineering, Xinxiang Medical University, Xinxiang, 453003, China.
Jie WuXinxiang Central Hospital, Xinxiang, 453000, China.
Wenqiang FanXinxiang Central Hospital, Xinxiang, 453000, China.
Junfang WuStem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Xinxiang Medical University, No. 601 East JinSui Road, Xinxiang, 453003, Henan Province, China. 562676314@qq.com.
Yanli LiuStem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Xinxiang Medical University, No. 601 East JinSui Road, Xinxiang, 453003, Henan Province, China. liuyanli198512@163.com.ORCID 0000-0003-0886-8907
Juntang LinStem Cell and Biotherapy Technology Research Center, School of Life Science and Technology, Xinxiang Medical University, No. 601 East JinSui Road, Xinxiang, 453003, Henan Province, China.

Funding

Henan Province Foundation No. LHGJ 20220989
6 · The paper itself

Abstract

Senescence is a degenerative process that occurs with ageing, and in the female reproductive system, senescence occurs earlier in the ovaries than in other tissues and organs, which implies a decrease in oocyte quality and exhaustion of the primordial follicular pool, leading to impaired ovarian function and an inability to maintain normal fertility. Unfortunately, the development of curative and effective treatments for ovarian senescence is still a considerable challenge. Currently, mesenchymal stem cells (MSCs)-based therapies for treating various refractory diseases, especially ovarian dysfunction, have been extensively studied and confirmed. However, the mechanisms by which MSCs improve ovarian senescence are not yet clear. Therefore, in this study, a mouse ageing model was generated via the intraperitoneal injection of a D-galactose (D-gal) solution, and the effects of menstrual blood-derived endometrial stem cells (MenSCs) transplantation on the ovarian follicle count, fibrosis level, and degree of apoptosis were evaluated. Subsequently, an ovarian granulosa cell ageing model was induced with H

Indexed as

Cellular SenescenceEndometriumInflammationMenstruationOvaryOxidative StressAgingAnimalsApoptosisFemaleHumansMesenchymal Stem CellsMiceMenstrual blood-derived endometrial stem cellsMitochondrial membrane potentialOvarian senescenceOxidative stressStem cell therapy

Identifiers

PMID39500850

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.