Evidence map›Paper›PMID 39500806›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2025

The effect of adipose-derived mesenchymal stem cells against high fructose diet induced liver dysfunction and dysbiosis.

Marwa Abdeltawab Mohammed, Nesma Hussein Abel Hay, Maha Tarek Mohammed, Hoda Sayed Mahmoud, Manar Yehia Ahmed, Ahmed Abdelmenem, Dina Sayed Abdelrahim

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Marwa Abdeltawab MohammedDepartment of Physiology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. marwadawaa777@gmail.com.
Nesma Hussein Abel HayDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Maha Tarek MohammedDepartment of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Hoda Sayed MahmoudDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Manar Yehia AhmedDepartment of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed AbdelmenemDepartment of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt.
Dina Sayed AbdelrahimDepartment of Clinical Pharmacology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High fructose diet (HFrD) has been approved to be involved in the pathogenesis of insulin resistance. Mesenchymal stem cells have a vital role in the treatment of various diseases including metabolic disturbances. We investigated the effect of Adipose-derived mesenchymal stem cells (ADMSCs) against HFrD-induced metabolic disorders and the molecular mechanisms for this effect. Rats were divided into 3 groups; control, HFrD, and combined HFrD with ADMSCs. We assessed liver functions, gut microbiota activity, oxidative stress, adiponectin, and IL10 levels. Also, we measured SREBP-1, IRS-1 expression using Western blot, and Malat1 expression using rt-PCR. ADMSCs antagonized metabolic abnormalities induced by HFrD in the form of improvement of liver functions and alleviation of oxidative stress. In addition, ADMSCs ameliorated gut microbiota activity besides the elevation of adiponectin and IL10 levels. ADMSCs attenuated insulin resistance through upregulation of IRS1 and downregulation of SREBP-1 and Malat1. ADMSCs can protect against HFrD-induced metabolic hazards.

Indexed as

Adipose TissueDysbiosisFructoseLiverLiver DiseasesMesenchymal Stem CellsMesenchymal Stem Cell TransplantationAdiponectinAnimalsGastrointestinal MicrobiomeInsulin Receptor Substrate ProteinsInsulin ResistanceInterleukin-10MaleOxidative StressRatsAdiponectinAdipoq protein, ratFructoseInsulin Receptor Substrate ProteinsInterleukin-10Irs1 protein, ratSrebf1 protein, ratSterol Regulatory Element Binding Protein 1MALAT-1Mesenchymal stem cellsNOX4SREBP-1

Identifiers

PMID39500806
PMCPMC11978704

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.