ArticleEuropean radiology2025
Feasibility, efficacy, and safety of core needle biopsy as a first-line method for cervical lymphadenopathy.
Article in European radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Diagnostic performance and timeliness of ultrasound-guided core needle biopsy for peripheral lymphadenopathy in Internal Medicine: a multicenter real-world study.Internal and emergency medicine · 2026Article
- Real-time CT/MR fusion imaging-guided core needle biopsy: enhancing diagnostic precision in head and neck lesions.Insights into imaging · 2026Article
- Ultrasound-Guided Needle Aspiration Biopsy for Superficial Cervical Lymphadenopathy: Diagnostic Yield Beyond Tuberculosis.Diagnostics (Basel, Switzerland) · 2026Article
- A multimodal feature disentanglement model for lymphadenopathy diagnosis based on BUS and CDFI ultrasound videos: a retrospective, prospective, multicenter study.European radiology · 2026Article
- Comparison of ultrasound-guided biopsy techniques for level IV lymph nodes: semiautomatic vs. Menghini modified needles in a retrospective dual-center study.BMC medical imaging · 2026Article
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Abstract
objectivesThis study aimed to determine the feasibility, diagnostic efficacy, and safety of ultrasound-guided core needle biopsy (CNB) as a first-line biopsy method for cervical lymphadenopathy of non-thyroid origin. MATERIALS AND
methodsThis retrospective cohort study included consecutive patients with cervical lymphadenopathy in whom US-guided CNB was used as the first-line biopsy method for cervical lymph nodes (LNs) of presumed non-thyroid origin. The coaxial CNB technique was routinely used, while the tilting and hydrodissection CNB techniques were selectively employed for small high-risk LNs. The primary endpoint of this study was the diagnostic efficacy of CNB, evaluated by the rate of inconclusive results (nondiagnostic and indeterminate) and diagnostic accuracy (criterion 1: malignant results; criterion 2: malignant or indeterminate result). The secondary outcomes included the feasibility and safety of CNB, assessed based on the technical success rate and complication rate, respectively.
resultsThe rates of nondiagnostic, indeterminate, and inconclusive results were 0.7%, 3.4%, and 4.1%, respectively. The sensitivity, specificity, and accuracy of CNB for malignant LNs were 96.2%, 100%, and 97.8%, respectively, with criterion 1, and these values were all 99.8% with criterion 2. The technical success rate of CNB was 99.3%. There were no major complications and 7 cases (0.6%) of minor complications (asymptomatic hematomas).
conclusionCNB was technically feasible, effective, and safe as a first-line biopsy method for cervical lymphadenopathy of non-thyroid origin with high diagnostic accuracy for malignant nodal disease. KEY POINTS: Question The role of US-guided CNB as a first-line biopsy method for cervical LNs has not yet been verified and established. Findings US-guided CNB, as a first-line method, demonstrated a high technical success rate and diagnostic accuracy for malignant nodes, with few minor complications. Clinical relevance US-guided CNB can be used as an effective first-line biopsy method for cervical lymphadenopathy and will enable accurate diagnosis of malignant LNs.
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