Evidence map›Paper›PMID 39500655›Full record

ReviewDifferentiation; research in biological diversity

The primary cilia: Orchestrating cranial neural crest cell development.

Hiroyuki Yamaguchi, Matthew D Meyer, William B Barrell, Maryam Faisal, Rebecca Berdeaux, Karen J Liu, Yoshihiro Komatsu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Differentiation; research in biological diversity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Ciliary-Mediated Mechanotransduction in Skeletal Development and Diseases.Results and problems in cell differentiation · 2026
    Review
  2. Disruption of distal appendage protein CEP164 causes skeletal malformation in mice.Biochemical and biophysical research communications · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hiroyuki YamaguchiDepartment of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.
Matthew D MeyerShared Equipment Authority, Rice University, Houston, TX, USA.
William B BarrellCentre for Craniofacial and Regenerative Biology, King's College London, SE1 9RT, London, UK.
Maryam FaisalDepartment of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA; Department of Bioengineering, Rice University George R. Brown School of Engineering, 77005, Houston, TX, USA.
Rebecca BerdeauxDepartment of Integrative Biology and Pharmacology, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA; CellChorus INC, Houston, TX, USA.
Karen J LiuCentre for Craniofacial and Regenerative Biology, King's College London, SE1 9RT, London, UK.
Yoshihiro KomatsuDepartment of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA; Graduate Program in Genetics & Epigenetics, The University of Texas MD Anderson Cancer Center UTHealth Graduate School of Biomedical Sciences, 77030, Houston, TX, USA. Electronic address: Yoshihiro.Komatsu@uth.tmc.edu.

Funding

Regulation of glucose utilization by skeletal muscle SIK1R01DK092590 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2011 to 2021
$3.3M
Promotion of satellite cell proliferation by cAMP signalingR01AR072368 · NIAMS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI BERDEAUX, REBECCA L · 2019 to 2023
$1.9M
The role of BMP signaling in craniofacial cartilage developmentR01DE025897 · NIDCR · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KOMATSU, YOSHIHIRO · 2017 to 2021
$1.8M
NIAMS NIH HHS R01 AR072368NIDCR NIH HHS R01 DE025897NIDDK NIH HHS R01 DK092590
6 · The paper itself

Abstract

Primary cilia (hereafter "cilia") are microtubule-based antenna-like organelles projecting from the surface of vertebrate cells. Cilia can serve as cellular antennae controlling cell growth and differentiation. Absent or dysfunctional cilia frequently lead to craniofacial anomalies known as craniofacial ciliopathies. However, the detailed pathological mechanisms of craniofacial ciliopathies remain unclear. This perspective discusses our current understanding of the role of cilia in cranial neural crest cells. We also describe potential mechanisms of ciliogenesis in cranial neural crest cells, which may contribute to unraveling the complex pathogenesis of craniofacial ciliopathies.

Indexed as

CiliaCiliopathiesNeural CrestSkullAnimalsCell DifferentiationHumansCiliaCiliogenesisCranial neural crest cellsCraniofacial developmentSignal transduction

Identifiers

PMID39500655
PMCPMC11911094

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.