Evidence map›Paper›PMID 39500611›Full record

ArticleBMJ open2024

Identifying priorities for future research on reducing and stopping psychiatric medication: results of a James Lind Alliance priority-setting partnership.

Miriam Boland, Agnes Higgins, Claire Beecher, Pat Bracken, Wendy Burn, Anne Cody, Adele Framer, Toto Gronlund, Mark Horowitz, Christy Huff and 8 more

Abstract read
In one paragraph

Article in BMJ open, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Miriam BolandSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.
Agnes HigginsSchool of Nursing and Midwifery, Trinity College Dublin, Dublin, Ireland.
Claire BeecherEvidence Synthesis Ireland and Cochrane Ireland, University of Galway, Galway, Ireland.
Pat BrackenIndependent Consultant Psychiatrist, West Cork, Ireland.
Wendy BurnLeeds and York Partnership NHS Foundation Trust, Leeds, UK.
Anne CodyHealth Research Board, Dublin, Ireland.
Adele FramerSurvivingAntidepressants.org, San Francisco, California, USA.
Toto GronlundJames Lind Alliance, NIHR, Llanrwst, UK.
Mark HorowitzGoodmayes Hospital, North East London NHS Foundation Trust, London, UK.ORCID http://orcid.org/0000-0003-1318-2029
Christy HuffBenzodiazepine Information Coalition, Utah, Utah, USA.
Sandra JayacodiLived Experience Public Contributor, London, UK.
Dolores KeatingPharmacy Department, St. John of God Hospital, Dublin, Ireland.ORCID http://orcid.org/0000-0001-7507-2680
David KesslerCentre for Academic Mental Health, Bristol Medical School, University of Bristol, Bristol, UK.
Åsa Konradsson-GeukenDepartment of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden.
Nicole LambersonBenzodiazepine Information Coalition, Utah, Utah, USA.
Luke MontaguCouncil for Evidence-based Psychiatry, London, UK.
Ruth SmithPublic Partner, Brighton, UK.
Cathal CadoganSchool of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland cathal.cadogan@tcd.ie.ORCID http://orcid.org/0000-0002-8778-0112

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe objective of this study is to identify the top 10 research priorities on reducing and stopping psychiatric medication that reflect the perspectives and unmet needs of three key stakeholder groups (people with lived experience, family members/carers/supporters and healthcare professionals).

methodsA priority-setting partnership was conducted using the James Lind Alliance's seven-step process. This involved (1) creating an international Steering Group of key stakeholder representatives and (2) identifying potential partners; (3) gathering stakeholders' uncertainties about reducing and stopping psychiatric medication using an online survey and summarising the survey responses; (4) checking the summary questions against existing evidence and verifying uncertainties; (5) shortlisting the questions using a second online survey; (6) determining the top 10 research questions through a prioritisation workshop; and (7) disseminating the results.

resultsA total of 3635 questions were collected in the initial survey from 884 respondents of which 32 questions were verified as uncertainties. These questions were then ranked in a second online survey by 526 respondents and the findings discussed in a final prioritisation workshop by 30 participants to produce the final top 10 list of research questions. These questions cover a range of areas including the most effective ways of safely reducing/stopping psychiatric medication and providing support to individuals undergoing the discontinuation process, as well as the best ways to educate healthcare professionals on this topic.

conclusionThe top 10 list of research priorities was produced through extensive engagement with key stakeholders and highlights important uncertainties and gaps in the existing evidence base that need to be addressed by future research.

Indexed as

Mental DisordersAdultCaregiversFemaleHealth PersonnelHealth PrioritiesHumansMaleMiddle AgedPsychotropic DrugsResearchStakeholder ParticipationSurveys and QuestionnairesPsychotropic DrugsAnxiety disordersDepression & mood disordersPSYCHIATRYSchizophrenia & psychotic disorders

Identifiers

PMID39500611
PMCPMC11552588

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.