ReviewAging and disease2024
Systemic Modulators: Potential Mechanism for the 5-HT System to Mediate Exercise Amelioration in Alzheimer's Disease.
Review in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Ginseng Bioactive Components as Gut-Brain Axis-Targeted Modulators: Therapeutic Potential and Mechanisms in Multifactorial Diseases.Nutrients · 2026Pooled it
- Research focus and trends of the association between gut microbiota and neuroinflammation.Frontiers in microbiology · 2025Pooled it
- Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review).International journal of molecular medicine · 2026Review
- Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans.Nature communications · 2026Article
- Beyond neurotransmission: the roles of serotonylation in physiological and pathological processes.Cellular & molecular biology letters · 2026Review
- Tryptophan metabolism alterations in neurological and psychiatric diseases: Molecular mechanisms and pharmacological targets.Metabolic brain disease · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
As a neurodegenerative disease closely related to age-related changes, Alzheimer's disease (AD) is rapidly becoming one of the most resource-intensive and deadly diseases of this century. As a systemic neurotransmitter system with widespread distribution throughout the central and peripheral nervous systems, the 5-hydroxytryptamine (5-HT) system not only plays an important role in antidepressant therapy but also shows potential value in improving AD symptoms. The 5-HT system may facilitate the prevention and treatment of AD by impacting its pathological processes through various pathways, such as the regulation of Aβ deposition, hyperphosphorylation of Tau, central and peripheral neuroinflammation, and the interactions with the cholinergic and BDNF systems. In addition, regular exercise, as a non-pharmacological intervention, provides systemic and multi-level physical health benefits. Given the high sensitivity of the 5-HT system to exercise, this paper reviews its crucial role and potential mechanisms in alleviating AD through exercise. From perspective of the integrative biology of exercise, we propose several crosstalk mechanisms between the peripheral and central systems mediated by the 5-HT system. These mechanisms serve as a bridge for the treatment of AD and offer novel ideas and strategies for future therapeutic approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.