Evidence map›Paper›PMID 39500355›Full record

ArticleAging and disease2024

Impairment of the trans-Golgi-Lysosomal Pathway Accelerates Dopaminergic Neuronal Senescence in LRRK2

Qiumei Yang, Shimin Pang, Chunsong Zhao, Yanyan Wang, Jing Lu, Zhenyu Yue, Piu Chan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. LRRK2NPJ Parkinson's disease · 2026
    Article
  3. Aging, cellular senescence and Parkinson's disease.Journal of Parkinson's disease · 2025
    Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qiumei YangDepartment of Neurobiology, Neurology and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Shimin PangDepartment of Neurobiology, Neurology and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Chunsong ZhaoDepartment of Neurobiology, Neurology and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Yanyan WangDepartment of Neurobiology, Neurology and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Jing LuDepartment of Neurobiology, Neurology and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.
Zhenyu YueDepartment of Neurobiology, Icahn School of Medicine at Mount Sinai, New York, USA.
Piu ChanDepartment of Neurobiology, Neurology and National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital of Capital Medical University, Beijing Institute of Geriatrics, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leucine-rich repeat kinase 2 (LRRK2)-R1628P mutation has been shown to be one of the common risk factors for Parkinson's disease (PD) in Asian populations, but the mechanism by which R1628P mutations cause neuronal dysfunction remains unknown. We used LRRK2

Indexed as

AgingCellular SenescenceDopaminergic NeuronsLeucine-Rich Repeat Serine-Threonine Protein Kinase-2Lysosomestrans-Golgi NetworkAnimalsHumansLipopolysaccharidesMaleMutationParkinson DiseaseRatsRats, TransgenicLeucine-Rich Repeat Serine-Threonine Protein Kinase-2LipopolysaccharidesLRRK2 protein, rat

Identifiers

PMID39500355
PMCPMC12339174

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.