Evidence map›Paper›PMID 39500315›Full record

ArticleStructure (London, England : 1993)2025

Structure-function analyses of human TRPV6 ancestral and derived haplotypes.

Arthur Neuberger, Alexey Shalygin, Yury A Trofimov, Irina I Veretenenko, Kirill D Nadezhdin, Nikolay A Krylov, Thomas Gudermann, Roman G Efremov, Vladimir Chubanov, Alexander I Sobolevsky

Abstract read
In one paragraph

Article in Structure (London, England : 1993), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. TRPV6 channel function is involved in endometrial epithelial cell CaCellular and molecular life sciences : CMLS · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Arthur NeubergerDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Alexey ShalyginWalther-Straub Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany.
Yury A TrofimovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Irina I VeretenenkoShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Kirill D NadezhdinDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Nikolay A KrylovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia.
Thomas GudermannWalther-Straub Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany; Comprehensive Pneumology Center, German Center for Lung Research, 81377 Munich, Germany.
Roman G EfremovShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 117997 Moscow, Russia; National Research University Higher School of Economics, 101000 Moscow, Russia.
Vladimir ChubanovWalther-Straub Institute of Pharmacology and Toxicology, LMU Munich, 80336 Munich, Germany.
Alexander I SobolevskyDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: as4005@cumc.columbia.edu.

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
Structure and Function of AMPA subtype ionotropic glutamate receptorsR01NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI KURNIKOVA, MARIA G, SOBOLEVSKY, ALEXANDER · 2013 to 2022
$4.3M
Structure and function of Transient Receptor Potential ChannelsR01CA206573 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2017 to 2026
$3.8M
Single-Particle Cryo-EM Characterization of AMPA Receptor Functional StatesR01NS107253 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2018 to 2026
$3.5M
Structural and functional principles of activation and regulation of the transient receptor potential channel TRPV3.R01AR078814 · NIAMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2022 to 2026
$2.8M
Structure and Function of Ionotropic Glutamate ReceptorsR37NS083660 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Alexander Sobolevsky · 2024 to 2026
$1.7M
NCI NIH HHS R01 CA206573NIAMS NIH HHS R01 AR078814NIGMS NIH HHS U24 GM129539NINDS NIH HHS R01 NS083660NINDS NIH HHS R01 NS107253NINDS NIH HHS R37 NS083660
6 · The paper itself

Abstract

TRPV6 is a Ca

Indexed as

CalciumCryoelectron MicroscopyHaplotypesModels, MolecularTRPV Cation ChannelsBinding SitesCalcium ChannelsCalmodulinHEK293 CellsHumansPolymorphism, Single NucleotideProtein BindingStructure-Activity RelationshipCalciumCalcium ChannelsCalmodulinTRPV6 protein, humanTRPV Cation Channelsancestralcancercryo-EMderiveddynamic molecular portraits of TRPV6 pore domainoncochannelTRP channelsTRPV6

Identifiers

PMID39500315
PMCPMC11698656

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.