Designing small-molecule and macromolecule sensors for imaging redox-active transition metal signaling.

Aidan T Pezacki, Jiaying Gao, Christopher J Chang

Abstract readReview

In one paragraph

Review in Current opinion in chemical biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it

0cells of the map it votes in

3citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

Molecular Design Strategies Enabling Activity-Based Sensing and Labeling as a Platform for Probing Enzyme Activity, Redox Regulation, and Transition-Metal Signaling.Bioconjugate chemistry · 2026
Review
Paradoxes in the Ontological Classification of Glia-Evidence for an Important New Class of Brain Cells with Primary Functions in Iron Regulation.Cells · 2026
Review
An Alkyne-Directed Cleavage Approach for Activity-Based Cu(I) Sensing Reveals Manganese-Promoted Sensitization of Cuproptosis.Journal of the American Chemical Society · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Aidan T PezackiDepartment of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

Jiaying GaoDepartment of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA.

Christopher J ChangDepartment of Chemistry, Princeton University, Princeton, NJ 08540, USA; Department of Chemistry, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA. Electronic address: chrischang@princeton.edu.

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026

$7.8M

Chemical Probes to Study Methionine Redox BiologyR01GM139245 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2020 to 2026

$2.9M

NIGMS NIH HHS R01 GM079465NIGMS NIH HHS R01 GM139245

6 · The paper itself

Abstract

Transition metals play essential roles in biology, where these nutrients regulate protein activity as active site cofactors or via metalloallostery. In contrast, dysregulation of transition metal homeostasis can lead to unique metal-dependent signaling pathways connected to aging and disease, such as cuproptosis and ferroptosis for copper- and iron-dependent cell death or cuproplasia and ferroplasia for copper- and iron-dependent cell growth and proliferation, respectively. New methods that enable detection of bioavailable transition metal pools with both metal and oxidation state specificity can help decipher their contributions to health and disease. Here we summarize recent advances in designing sensors for imaging transition metals and their applications to uncover new metal biology.

Indexed as

Oxidation-ReductionSignal TransductionTransition ElementsAnimalsBiosensing TechniquesHumansMacromolecular SubstancesSmall Molecule LibrariesMacromolecular SubstancesSmall Molecule LibrariesTransition Elements

Identifiers

PMID39500078

DOI10.1016/j.cbpa.2024.102541

PMCPMC11588540

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.