Evidence map›Paper›PMID 39499872›Full record

Observational studyNeurology2024

Association of Cerebrovascular Reactivity With 1-Year Imaging and Clinical Outcomes in Small Vessel Disease: An Observational Cohort Study.

Emilie Sleight, Michael S Stringer, Una Clancy, Carmen Arteaga-Reyes, Daniela Jaime Garcia, Angela C C Jochems, Stewart Wiseman, Maria Valdes Hernandez, Francesca M Chappell, Fergus N Doubal and 3 more

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Optimal markers of treatment response to vasodilatory drugs in small vessel disease: An OxHARP trial analysis.International journal of stroke : official journal of the International Stroke Society · 2026
    Trial
  3. Article
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Imaging brain fluid dynamics and waste clearance involving perivascular spaces in cerebral small vessel disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emilie SleightFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0003-0034-4578
Michael S StringerFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0002-3811-4439
Una ClancyFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0002-8062-7537
Carmen Arteaga-ReyesFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0003-2424-7123
Daniela Jaime GarciaFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0002-9457-9855
Angela C C JochemsFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0001-7392-3066
Stewart WisemanFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0001-6739-5797
Maria Valdes HernandezFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.
Francesca M ChappellFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0002-7742-1757
Fergus N DoubalFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0002-2769-3148
Ian MarshallFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.
Michael J ThrippletonFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0001-7858-9917
Joanna M WardlawFrom the Centre for Clinical Brain Sciences (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.) and UK Dementia Research Institute (E.S., M.S.S., U.C., C.A.-R., D.J.G., A.C.C.J., S.W., M.V.H., F.M.C., F.N.D., I.M., M.T., J.M.W.), University of Edinburgh, United Kingdom. Michael Thrippleton and Joanna Wardlaw are currently at Edinburgh Imaging Facility, Royal Infirmary of Edinburgh, University of Edinburgh, United Kingdom.ORCID 0000-0002-9812-6642

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesIn patients with cerebral small vessel disease (SVD), impaired cerebrovascular reactivity (CVR) is related to worse concurrent SVD burden, but less is known about cerebrovascular reactivity and long-term SVD lesion progression and clinical outcomes. We investigated associations between cerebrovascular reactivity and 1-year progression of SVD features and clinical outcomes.

methodsBetween 2018 and 2021, we recruited patients from the Edinburgh/Lothian stroke services presenting with minor ischemic stroke and SVD features as part of the Mild Stroke Study 3, a prospective observational cohort study (ISRCTN 12113543). We acquired 3T brain MRI at baseline and 1 year. At baseline, we measured cerebrovascular reactivity to 6% inhaled CO

resultsWe recruited 208 patients of whom 163 (mean age and SD: 65.8 ± 11.2 years, 32% female) had adequate baseline CVR and completed the follow-up structural MRI. The median increase in WMH volume was 0.32 mL with (Q1, Q3) = (-0.48, 1.78) mL; 29% had a recurrent stroke or incident infarct on MRI. At 1 year, patients with lower baseline cerebrovascular reactivity in normal-appearing tissues had increased WMH (regression coefficient: B = -1.14 [-2.13, -0.14] log DISCUSSION: Lower baseline cerebrovascular reactivity predicted an increase in WMH and perivascular space volumes after 1 year. CVR should be considered in SVD future research and intervention studies.

Indexed as

Cerebral Small Vessel DiseasesMagnetic Resonance ImagingAgedBrainCerebrovascular CirculationCohort StudiesDisease ProgressionFemaleHumansIschemic StrokeMaleMiddle AgedProspective StudiesWhite Matter

Identifiers

PMID39499872
PMCPMC11540458

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