Evidence map›Paper›PMID 39499788›Full record

ArticleMedical physics2025

Multi-organ kinetic modeling for Na[

Jose Benitez-Aurioles, Paul S Clegg, Carlos J Alcaide-Corral, Catriona Wimberley, Adriana A S Tavares

Abstract read
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In one paragraph

Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jose Benitez-AuriolesSchool of Physics & Astronomy, University of Edinburgh, Edinburgh, UK.
Paul S CleggSchool of Physics & Astronomy, University of Edinburgh, Edinburgh, UK.
Carlos J Alcaide-CorralEdinburgh Imaging, University of Edinburgh, Edinburgh, UK.
Catriona WimberleySchool of Physics & Astronomy, University of Edinburgh, Edinburgh, UK.
Adriana A S TavaresEdinburgh Imaging, University of Edinburgh, Edinburgh, UK.

Funding

British Heart Foundation FS/19/34/34354Chan Zuckerberg Initiative DAF 2020-225273Silicon Valley Community FoundationWellcome TrustWellcome Trust TDA 221295/Z/20/Z
6 · The paper itself

Abstract

backgroundTotal-body positron emission tomography (PET), already well-established in the pre-clinical setting, makes it possible to study multi-parameters in biological systems as a whole, rather than focusing on single tissues analysis. Simultaneous kinetic analysis of multiple organs poses some daunting new challenges. PURPOSE: To explore quantifying the pharmacokinetics of Na[

methodsSix mice underwent a 60-min total-body PET scan following intravenous bolus injection of Na[

resultsThe models give a good qualitative account of the activity curves irrespective of the duration of the data; however, the quality of the fits to 3 min of data (average

conclusionThe present study demonstrates an approach to performing kinetic modeling for multiple organs simultaneously with Na[

Indexed as

Fluorine RadioisotopesModels, BiologicalPositron-Emission TomographySodiumWhole Body ImagingAnimalsKineticsMiceFluorine-18Fluorine RadioisotopesSodiumcalcificationkinetic modelingNa[18F]Fperfusiontotal‐body PET

Identifiers

PMID39499788
PMCPMC11788250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.