Evidence map›Paper›PMID 39499491›Full record

ArticleGeneral thoracic and cardiovascular surgery2025

Mitochondrial respiratory pathways in immature rat heart tissue using different cardioplegic solutions.

Arslan Mamedov, Eglė Rumbinaitė, Sebastian Romann, Dovydas Verikas, Povilas Jakuška, Serik Aitaliyev, Rimantas Benetis, Edgaras Stankevičius

Erratum issuedAbstract readComparative Study
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In one paragraph

Article in General thoracic and cardiovascular surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Arslan MamedovDepartment of Cardiac, Thoracic and Vascular Surgery, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Eglė RumbinaitėDepartment of Cardiology, of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Sebastian RomannDepartment of Internal Medicine III: Cardiology, Angiology & Pulmonology, Heidelberg University Hospital, Heidelberg, Germany.
Dovydas VerikasDepartment of Cardiology, of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Povilas JakuškaDepartment of Cardiac, Thoracic and Vascular Surgery, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Serik AitaliyevDepartment of Cardiac, Thoracic and Vascular Surgery, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania. aitaliyev.serik@gmail.com.ORCID http://orcid.org/0000-0002-3014-9100
Rimantas BenetisDepartment of Cardiac, Thoracic and Vascular Surgery, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Edgaras StankevičiusInstitute of Physiology and Pharmacology, Faculty of Medicine, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMinor defects in the mitochondrial ATP-generating system and post-cardioplegia oxidative phosphorylation can negatively impact cardiac function in immature hearts. This study aimed to examine the mitochondrial respiratory pathway using three different cardioplegic solutions (Custodiol HTK, St. Thomas, and Del Nido) during moderate (1 h) and long (3 h) ischemic periods.

methodsA total of 41 male Wistar albino rats were utilized in this study. Five experiments were conducted without the use of any cardioplegic solution (CP0 group). To assess both moderate and prolonged ischemic periods, six experiments were carried out in each of the following groups: CP1 group (St. Thomas solution), CP2 group (Custodiol HTK solution), and CP3 group (Del Nido solution).

resultsAfter 1 h, the highest mitochondrial respiration rate was observed in the CP3 group and the lowest in the CP1 group (p = 0.006). After adding ADP substrate, the highest mitochondrial ATP-production-coupled respiration was recorded in the CP3 group, which was similar to the control group CP0. After 3 h, while evaluating the ratio between mitochondrial respiration ATP-production coupled and basal respiration, significant differences were found between CP1 group and CP3 group (p = 0.035), as well as between the CP1 and CP0 groups (p = 0.045). Additionally, by assessing the condition of the outer mitochondrial membrane using the Cyt C effect (Cyt/Phos [ADP]), significant differences were observed between the CP1 and CP3 group (p = 0.004), as well as between CP1 and CP0 groups (p = 0.003).

conclusionDel Nido cardioplegic solution provided optimal mitochondrial protection under moderate and long myocardial ischemia conditions.

Indexed as

Cardioplegic SolutionsEnergy MetabolismHeart Arrest, InducedMitochondria, HeartMyocardial Reperfusion InjuryAdenosine TriphosphateAnimalsCell RespirationMaleOxidative PhosphorylationPotassium ChlorideProcaineRatsRats, WistarTime FactorsAdenosine TriphosphateCardioplegic SolutionsPotassium ChlorideProcaineCustodiol HTK cardioplegic solutionDel Nido cardioplegic solutionMitochondrial respirationMyocardial ischemiaPediatric cardiac surgerySt. Thomas cardioplegic solution

Identifiers

PMID39499491

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.