Evidence map›Paper›PMID 39499431›Full record

ArticleVirus genes2025

Genetic characterization of influenza B virus and oseltamivir resistance in pediatric patients with acute respiratory infections: a cross-sectional study.

Sheida Alizadeh, Fahime Edalat, Arash Letafati, Neda Pirbonyeh, Alireza Tabibzadeh, Leila Mousavizadeh, Afagh Moattari, Mohammad Hadi Karbalaie Niya

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Article in Virus genes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sheida AlizadehDepartment of Virology and Bacteriology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Fahime EdalatAutophagy Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Arash LetafatiDepartment of Virology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
Neda PirbonyehDepartment of Virology and Bacteriology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Alireza TabibzadehDepartment of Medical Laboratory Sciences, Faculty of Medical Sciences, Islamic Azad University, Arak Branch, Arak, Iran.
Leila MousavizadehDepartment of Virology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Afagh MoattariDepartment of Virology and Bacteriology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. moattaria@sums.ac.ir.
Mohammad Hadi Karbalaie NiyaGastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran. Karbalai.mh@iums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Influenza virus neuraminidase inhibitors (NAIs) drug usage can result in NAI resistance, especially in children and individuals with weakened immune systems. The aim of the present study was to identify NAI-resistant variants of IBV and to introduce probable novel mutations, phylogenetic study, and its epitope mapping based on NA gene in patients from Shiraz, Iran. A cross-sectional study was conducted between 2017 and 2018 on symptomatic children. A real-time PCR was run for IBV screening. Then, making use of direct sequencing, amplified 1401 bases of NA gene and phylogenetic tree reconstructed. Epitopes were predicted using ABCpred server. From among a total of 235 specimens, 9.7% were identified with IBV infection. Of them, sequence of NA gene for 17 isolates were analyzed. Phylogenetic analysis showed that 15 isolates belonged to Yamagata clade 3 Wisconsin/01-like subclade and 2 were related to Victoria clade 1 Brisbane/60-like subclade (Vic-1A-2). NA gene sequence analysis showed a total of 52 substitutions in which 27 were for B

Indexed as

Drug Resistance, ViralInfluenza B virusInfluenza, HumanOseltamivirRespiratory Tract InfectionsAdolescentAntiviral AgentsChildChild, PreschoolCross-Sectional StudiesFemaleHumansInfantIranMaleMutationAntiviral AgentsNeuraminidaseOseltamivirViral ProteinsDrug resistanceInfluenza BMutationNeuraminidase inhibitors

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.