ArticleStrahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]2025
CBCT-based online adaptive radiotherapy of the prostate bed: first clinical experience and comparison to nonadaptive conventional IGRT.
Article in Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed.
- Intra-adaptational motion during online adaptive radiotherapy: analysis of couch shifts and implications for margin design.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2026Article
- Uncertainty estimation for reliable neural network-based radiotherapy dose modelling using Monte Carlo dropout, mean variance estimation and deep ensemble.Physics and imaging in radiation oncology · 2026Article
- Development of CBCT-Guided Online Adaptive Radiotherapy.Cancers · 2026Review
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- CBCT based online daily adaptive treatment improves target coverage with limited benefit for OAR protection in SBRT prostate cancer.Radiation oncology (London, England) · 2026Article
- Article
- Refining imaging parameters for dual-energy cone-beam computed tomography in image-guided radiation therapy.Journal of applied clinical medical physics · 2026Article
- Survey data analysis of treatment planning methods in particle therapy facilities.Japanese journal of radiology · 2026Article
- Accumulated dose on daily iCBCT for rectal cancer: Effects of inter-fraction bowel cavity motion volume.Journal of applied clinical medical physics · 2026Article
- Clinical experience with an online adaptive radiotherapy for prostate cancer: successful treatment time optimization.BMC cancer · 2026Article
- Cone beam computed tomography-guided online adaptive radiation therapy: Clinical implementation in breast and axillary target volumes.Clinical and translational radiation oncology · 2026Article
- [Simulation-free radiation therapy in palliative care].Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- Intra-adaptational changes in online adaptive radiotherapy: from the ideal to the real dose.Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2025Article
- A cone-beam computed tomography based workflow for online adaptive ultra-hypofractionated radiotherapy of prostate cancer.Physics and imaging in radiation oncology · 2025Article
- Optimizing Workflow for Cone Beam Computed Tomography-Based Online Adaptive Radiation Therapy Toward Reduced Physician Involvement.Advances in radiation oncology · 2025Article
- CBCT-based online adaptive radiotherapy of the bladder - geometrical and dosimetrical considerations compared to conventional IGRT.Radiation oncology (London, England) · 2025Article
- Improving segmentation precision in prostate cancer adaptive radiation therapy with a patient-specific network.PloS one · 2025Article
- Daily online adaptation enhances target coverage in prostate cancer radiotherapy: a retrospective analysis.Frontiers in oncology · 2025Article
- CBCT-based Online Adaptive Radiotherapy for Prostate Cancer: Dosimetrical Aspects and Comparison to Non-Adaptive Conventional IGRT.Technology in cancer research & treatmentArticle
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18 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeConventional image-guided radiotherapy (IGRT) of the prostate bed is challenged by the varying anatomy due to dynamic changes of surrounding organs such as the bladder and rectum. This leads to changed dose coverage of target and surrounding tissue. The novel online adaptive radiotherapy (oART) aims to improve target coverage as well as reduce dose exposure to surrounding healthy tissues by daily reoptimization of treatment plans. Here we set out to quantify the resulting changes of this adaptation for patients and treatment team.
methodsA total of 198 fractions of radiotherapy of the prostate bed (6 patients) were treated using oART with the Ethos accelerator (Varian Medical Systems, Palo Alto, CA, USA). For each fraction, volumes and several dose-volume parameters of target volumes and organs at risk were recorded for the scheduled plan (initial plan, recalculated based on daily cone beam computed tomography [CBCT]), the adapted plan, and the verification plan, which is the dose distribution of the applied plan recalculated on the closing CBCT after the adaptation process. Clinical acceptability for all plans was determined using given dose-volume parameters of target volumes. Additionally, the time needed for the adaptation process was registered and compared to the time required for the daily treatment of five conventional IGRT patients.
resultsVolumes of target and organs at risk (OAR) exhibited broad variation from day to day. The differences in dose coverage D
conclusionTarget dose coverage was significantly improved using oART. IQR decreased for target coverage as well as OAR doses indicating higher repeatability of dose delivery using oART. Differences in doses after verification CBCT for targets as well as OAR were significant compared to adapted plans but did not offset the overall dosimetric gain of oART. The median time required is three times higher for oART compared to IGRT.
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