Evidence map›Paper›PMID 39499253›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2025

Obesogenic cafeteria diet induces dynamic changes in gut microbiota, reduces myenteric neuron excitability, and impairs gut contraction in mice.

Luis M Ramírez-Maldonado, Julio Guerrero-Castro, José L Rodríguez-Mejía, Yair Cárdenas-Conejo, Edgar O Bonales-Alatorre, Georgina Valencia-Cruz, Paulina T Anguiano-García, Irving I Vega-Juárez, Adán Dagnino-Acosta, Jessica Ruvalcaba-Galindo and 5 more

Abstract read
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In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
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  6. Diet-microbiome-ENS connection: impact of the cafeteria diet.American journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Luis M Ramírez-MaldonadoCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.ORCID 0009-0009-1798-7829
Julio Guerrero-CastroCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
José L Rodríguez-MejíaCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
Yair Cárdenas-ConejoLaboratorio de Biología Sintética Estructural y Molecular, Universidad de Colima-Consejo Nacional de Humanidades, Ciencias y Tecnologías, Colima, México.
Edgar O Bonales-AlatorreCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
Georgina Valencia-CruzCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
Paulina T Anguiano-GarcíaCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
Irving I Vega-JuárezCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
Adán Dagnino-AcostaCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.ORCID 0000-0001-8903-807X
Jessica Ruvalcaba-GalindoCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.
Eduardo E Valdez-MoralesDepartamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes-Consejo Nacional de Humanidades, Ciencias y Tecnologías, Aguascalientes, México.
Fernando Ochoa-CortesEscuela Superior de Huejutla, Universidad Autónoma del Estado de Hidalgo, Huejutla de Reyes, Hidalgo, México.
Alma Barajas-EspinosaEscuela Superior de Huejutla, Universidad Autónoma del Estado de Hidalgo, Huejutla de Reyes, Hidalgo, México.
Raquel Guerrero-AlbaDepartamento de Fisiología y Farmacología, Centro de Ciencias Básicas, Universidad Autónoma de Aguascalientes, Aguascalientes, México.ORCID 0000-0001-6010-1012
Andrómeda Liñán-RicoCentro Universitario de Investigaciones Biomédicas (CUIB), Universidad de Colima, Colima, México.ORCID 0000-0001-8370-7316

Funding

Consejo Nacional de Humanidades, Ciencias y Tecnologías (Conahcyt) 21854
6 · The paper itself

Abstract

The cafeteria diet (CAF) is a superior diet model in animal experiments compared with the conventional high-fat diet (HFD), effectively inducing obesity, metabolic disturbances, and multi-organ damage. Nevertheless, its impact on gut microbiota composition during the progression of obesity, along with its repercussions on the enteric nervous system (ENS) and gastrointestinal motility has not been completely elucidated. To gain more insight into the effects of CAF diet in the gut, C57BL/6 mice were fed with CAF or a standard diet for 2 or 8 wk. CAF-fed mice experienced weight gain, disturbed glucose metabolism, dysregulated expression of colonic IL-6, IL-22, TNFα, and TPH1, and altered colon morphology, starting at

Indexed as

Diet, High-FatGastrointestinal MicrobiomeGastrointestinal MotilityMice, Inbred C57BLObesityAnimalsColonMaleMiceMyenteric PlexusNeuronscafeteria dietdysbiosisgut contractionsmyenteric neuronsobesity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.