ArticleJournal of the American Geriatrics Society2025
Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.
Article in Journal of the American Geriatrics Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Parkinsonian signs and cognitive trajectories in older adults: a population-based longitudinal study.Age and ageing · 2026Article
- Motor-Derived Digital Biomarkers for Identifying Low-MoCA Status in People with Parkinson's Disease.Sensors (Basel, Switzerland) · 2026Article
- Associations Between Cognitive Performance and Motor Signs in Older Adults with Alzheimer's Dementia.Medicina (Kaunas, Lithuania) · 2025Article
- Factors associated with motor manifestations in older adults with Alzheimer's dementia: a cross-sectional analysis.European geriatric medicine · 2025Article
- Apolipoprotein E Alleles and Motor Signs in Older Adults with Alzheimer's Dementia.International journal of molecular sciences · 2025Article
- Neuropsychiatric Symptoms and White Matter Hyperintensities in Older Cognitively Unimpaired Men Versus Women.International journal of geriatric psychiatry · 2025Article
- Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.Journal of the American Geriatrics Society · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundMotor signs may herald incident dementia and allow the earlier detection of high-risk individuals and the timely implementation of preventive interventions. The current study was performed to investigate the prognostic properties of motor signs with respect to incident dementia with Lewy bodies (DLB) in older adults with mild cognitive impairment (MCI). Emphasis was placed on sex differences. The specificity of these associations was explored.
methodsWe analyzed data from the National Alzheimer's Coordinating Center Uniform Data Set. Participants 55 + years old with a diagnosis of MCI were included in the analysis. Those with Parkinson's disease (PD) or other parkinsonian disorders at baseline and those with PD dementia at follow-up were excluded. UPDRS III was used to assess the presence or absence of motor signs in nine domains: hypophonia; masked facies; resting tremor; action/postural tremor; rigidity; bradykinesia; impaired chair rise; impaired posture/gait; postural instability. Αdjusted Cox proportional hazards models featuring sex by motor sign interactions were estimated.
resultsThroughout the average follow-up of 3.7 ± 3.1 years, among 4623 individuals with MCI, 2211 progressed to dementia (66 of whom converted to DLB). Masked facies [HR = 4.21 (1.74-10.18)], resting tremor [HR = 4.71 (1.44-15.40)], and bradykinesia [HR = 3.43 (1.82-6.45)] exclusively increased the risk of DLB. The HR of DLB was approximately 15 times greater in women compared to men with masked facies. Impaired posture-gait (approximately 10 times) and resting tremor (approximately 8.5 times) exhibited a similar trend (prominent risk-conferring properties in women compared to men) but failed to achieve statistical significance. Rigidity and hypophonia elevated the risk of other dementia entities, as well. The remaining motor features were not related to incident dementia of any type.
conclusionsSpecific motor signs may herald DLB among individuals with MCI. Different associations may exist between masked facies, impaired posture-gait, resting tremor, and incident DLB in men versus women.
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