ArticleeLife2024
Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- An image-computable spatio-chromatic receptive field model of the midget retinal ganglion cell mosaic across the retina.Journal of computational neuroscience · 2026Article
- Origin and functional impact of early nonlinearities in primate retina.bioRxiv : the preprint server for biology · 2026Article
- Nutritional Status and Nitrogen Uptake Dynamics of Waxy-Type Winter Wheat Under Liquid Organic Fertilization.Plants (Basel, Switzerland) · 2025Article
- Predictably manipulating photoreceptor light responses to reveal their role in downstream visual responses.eLife · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
Computation in neural circuits relies on the judicious use of nonlinear circuit components. In many cases, multiple nonlinear components work collectively to control circuit outputs. Separating the contributions of these different components is difficult, and this limits our understanding of the mechanistic basis of many important computations. Here, we introduce a tool that permits the design of light stimuli that predictably alter rod and cone phototransduction currents - including stimuli that compensate for nonlinear properties such as light adaptation. This tool, based on well-established models for the rod and cone phototransduction cascade, permits the separation of nonlinearities in phototransduction from those in downstream circuits. This will allow, for example, direct tests of how adaptation in rod and cone phototransduction affects downstream visual signals and perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.