ArticleMovement disorders clinical practice2024
Respiratory Dysfunction and Abnormal Hypoxic Ventilatory Response in Mild to Moderate Parkinson's Disease.
Article in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Hypoxic conditioning in Parkinson's disease: randomized controlled multiple N-of-1 trials.Nature communications · 2025Trial
- Respiratory Variability during Exercise: Associations with Motor Severity in Parkinson's Disease.Movement disorders clinical practice · 2026Article
- Pulmonary Function in Parkinson's Disease: A Comparative Study of Spirometry and Impulse Oscillometry.Biomedicines · 2026Article
- Neonatal inflammation induces lasting sex- and region-dependent microglia activation and sex-dependent impairments in chemoreflexes.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Improved oxygen saturation after deep brain stimulation in Parkinson's disease.Neurosurgical review · 2025Article
- Chest mobility, cough strength, muscle strength, physical activity, and quality of life in parkinson's patients who had COVID-19.BMC pulmonary medicine · 2025Article
- How reducing oxygen-transport may lower the risk of developing Parkinson's disease.NPJ Parkinson's disease · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
backgroundRespiratory dysfunction is an important contributor to morbidity and mortality in advanced Parkinson's disease (PD), but it is unclear what parameters are sensitive to diagnose and monitor respiratory dysfunction across disease phases.
objectivesWe aimed to characterize respiratory dysfunction in mild to moderate PD.
methodsIn 20 individuals without cardiopulmonary comorbidity, pulmonary and inspiratory muscle function testing were performed ON-medication. Subsequently, the acute ventilatory response to hypoxia (HVR) was assessed by gradually decreasing F
resultsAt rest, individuals with greatest PD severity had a lower tidal volume (pairwise comparisons: 0.59 vs. 0.74, P = 0.038-0.050) and tended to have a higher breathing frequency (17.7 vs. 14.4, P = 0.076), despite normal pulmonary function. A 45-min exposure to hypoxia induced a significantly lower acute HVR in individuals with PD compared to controls (-0.0489 vs. 0.133 L.min/%, P = 0.0038). Acute HVR was reduced regardless of disease severity. Subacute HVR in individuals with milder disease tended to be higher compared to those with more advanced disease (P = 0.079).
conclusionsRespiratory dysfunction is present in individuals with PD, including those with relatively mild disease severity, and is characterized by altered breathing patterns at rest, as well as a lower HVR, despite normal pulmonary and inspiratory muscle function testing.
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Registered trials
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