Evidence map›Paper›PMID 39498750›Full record

ReviewAdvanced healthcare materials2025

3D-Printed Polymeric Biomaterials for Health Applications.

Yuxiang Zhu, Shenghan Guo, Dharneedar Ravichandran, Arunachalam Ramanathan, M Taylor Sobczak, Alaina F Sacco, Dhanush Patil, Sri Vaishnavi Thummalapalli, Tiffany V Pulido, Jessica N Lancaster and 15 more

Abstract readReview
In one paragraph

Review in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Yuxiang ZhuManufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.ORCID 0000-0001-5688-5600
Shenghan GuoManufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.ORCID 0000-0002-2159-6128
Dharneedar RavichandranManufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.ORCID 0000-0003-0393-7934
Arunachalam RamanathanSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0003-4683-5663
M Taylor SobczakSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Alaina F SaccoSchool of Chemical, Materials and Biomedical Engineering (CMBE), College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Dhanush PatilManufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.ORCID 0000-0003-0093-3997
Sri Vaishnavi ThummalapalliSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.ORCID 0009-0002-5903-6131
Tiffany V PulidoDepartment of Immunology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA.
Jessica N LancasterDepartment of Immunology, Mayo Clinic Arizona, 13400 E Shea Blvd, Scottsdale, AZ, 85259, USA.ORCID 0000-0003-0398-9988
Johnny YiDepartment of Medical and Surgical Gynecology, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.ORCID 0000-0002-7480-6344
Jeffrey L CornellaDepartment of Medical and Surgical Gynecology, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ, 85054, USA.
David G LottDivision of Laryngology, Department of Otolaryngology, Mayo Clinic Arizona, Phoenix, AZ, USA.
Xiangfan ChenManufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.ORCID 0000-0002-5627-7530
Xuan MeiDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.ORCID 0000-0002-1190-0800
Yu Shrike ZhangDivision of Engineering in Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA, 02139, USA.ORCID 0000-0002-0045-0808
Linbing WangSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0003-2670-376X
Xianqiao WangSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0003-2461-3015
Yiping ZhaoPhysics, Franklin College of Arts and Sciences, University of Georgia, Athens, GA, 30602, USA.ORCID 0000-0002-3710-4159
Mohammad K HassanCenter for Advanced Materials, Qatar University, Doha, 2713, Qatar.ORCID 0000-0002-5316-2463
Lindsay B ChambersSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Taylor G TheobaldSchool of Environmental, Civil, Agricultural, and Mechanical Engineering (ECAM), College of Engineering, University of Georgia, Athens, GA, 30602, USA.
Sui YangMaterials Science and Engineering, School for Engineering of Matter, Transport and Energy (SEMTE) at Arizona State University, Tempe, AZ, 85287, USA.ORCID 0000-0002-4072-6856
Liang Liang123DTechs Inc, Athens, GA, 30602, USA.
Kenan SongManufacturing Engineering, The School of Manufacturing Systems and Networks (MSN), Ira A. Fulton Schools of Engineering, Arizona State University (ASU), Mesa, AZ, 85212, USA.ORCID 0000-0002-0447-2449

Funding

High-throughput Imaging-integrated Vascular Model for Understanding Thromboembolism and Therapeutics ScreeningR01HL166522 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Junjie Yao, Y. Shrike Zhang · 2023 to 2026
$2.7M
Biomaterials for embolization and ablation of arterio-venous malformationsR01HL165176 · NHLBI · MAYO CLINIC ARIZONA · PI OKLU, RAHMI, ZHANG, Y. SHRIKE · 2022 to 2025
$2.6M
Stretchable Hydrogel Bioinks-Enabled Microfluidic Bioprinting of Functional Small-Diameter Blood VesselsR01HL153857 · NHLBI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI ZHAO, XUANHE · 2020 to 2024
$2.4M
A Bioprinted Volumetric Model of Vascularized GlioblastomaR01CA282451 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI Kaisorn Lee Chaichana, Y. Shrike Zhang · 2023 to 2026
$1.7M
Handheld Wound Analyzer for in situ HealingR01GM134036 · NIGMS · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2020 to 2023
$1.4M
Development of An Optoelectronically Active BioinkR21EB030257 · NIBIB · UNIVERSITY OF HOUSTON · PI YU, CUNJIANG · 2020 to 2020
$694k
Cryobioprinting for Shelf-Ready Tissue Fabrication and StorageR56EB034702 · NIBIB · BRIGHAM AND WOMEN'S HOSPITAL · PI ZHANG, Y. SHRIKE · 2023 to 2023
$499k
Modeling Sex-Specific Cardiac Hypertrophy-on-a-ChipR21HL168656 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MAHARJAN, SUSHILA, ZHANG, Y. SHRIKE · 2024 to 2025
$492k
Arizona Biomedical Research Centre RFGA2022-010-07ASU Women and Philanthropy FoundationBrigham Research InstituteChan Zuckerberg Initiative 2022-316712Mayo Clinic and Arizona State University Alliance for Health Care Collaborative Research Seed GrantNational Institutes of Technology R01CA282451National Institutes of Technology R01GM134036National Institutes of Technology R01HL153857National Institutes of Technology R01HL165176National Institutes of Technology R01HL166522National Institutes of Technology R21EB030257National Institutes of Technology R21HL168656National Institutes of Technology R56EB034702National Science Foundation CBET-EBMS-1936105National Science Foundation CISE-IIS-2225698National Science Foundation Graduate Research Fellowship Program GRFP 1000375560NCI NIH HHS R01 CA282451NHLBI NIH HHS R01 HL153857NHLBI NIH HHS R01 HL165176NHLBI NIH HHS R01 HL166522NHLBI NIH HHS R21 HL168656NIBIB NIH HHS R21 EB030257NIBIB NIH HHS R56 EB034702NIGMS NIH HHS R01 GM134036NSF Faculty Early Career Development Program 2145895NSF Graduate Research Fellowships ProgramQatar National Research Fund NPRP14S-0317-210064
6 · The paper itself

Abstract

3D printing, also known as additive manufacturing, holds immense potential for rapid prototyping and customized production of functional health-related devices. With advancements in polymer chemistry and biomedical engineering, polymeric biomaterials have become integral to 3D-printed biomedical applications. However, there still exists a bottleneck in the compatibility of polymeric biomaterials with different 3D printing methods, as well as intrinsic challenges such as limited printing resolution and rates. Therefore, this review aims to introduce the current state-of-the-art in 3D-printed functional polymeric health-related devices. It begins with an overview of the landscape of 3D printing techniques, followed by an examination of commonly used polymeric biomaterials. Subsequently, examples of 3D-printed biomedical devices are provided and classified into categories such as biosensors, bioactuators, soft robotics, energy storage systems, self-powered devices, and data science in bioplotting. The emphasis is on exploring the current capabilities of 3D printing in manufacturing polymeric biomaterials into desired geometries that facilitate device functionality and studying the reasons for material choice. Finally, an outlook with challenges and possible improvements in the near future is presented, projecting the contribution of general 3D printing and polymeric biomaterials in the field of healthcare.

Indexed as

Biocompatible MaterialsPolymersPrinting, Three-DimensionalBiosensing TechniquesHumansBiocompatible MaterialsPolymersadvanced manufacturingbiomedicalhealthcarepharmaceuticalregenerative medicine

Identifiers

PMID39498750
PMCPMC11694096

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.