Evidence map›Paper›PMID 39498599›Full record

ArticleEuropean journal of haematology2025

Biomarkers to Differentiate Acute Chest Syndrome From Vaso-Occlusive Crisis in Children With Sickle Cell Disease.

Karen Wang, Nelida Olave, Saurabh Aggarwal, Joo-Yeun Oh, Rakesh P Patel, A K M Fazlur Rahman, Jeffrey Lebensburger, Ammar Saadoon Alishlash

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Article in European journal of haematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Karen WangHeersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Nelida OlaveDepartment of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Saurabh AggarwalDepartment of Cellular and Molecular Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida, USA.
Joo-Yeun OhDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Rakesh P PatelDepartment of Pathology, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
A K M Fazlur RahmanDepartment of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Jeffrey LebensburgerDepartment of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.
Ammar Saadoon AlishlashDepartment of Pediatrics, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Funding

Project 2: Leveraging Ongoing Home Visitation Programs to Address Obesity Disparities among Underserved, Low-Income Mothers and ChildrenU54MD000502 · NIMHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SALVY, SARAH-JEANNE · 2017 to 2022
$11.8M
Chronic Widespread Pain in HIV: Novel Mechanisms and TherapeuticsR01DA049657 · NIDA · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2025
$1.8M
Identification of AMD3100 (Plerixafor) as a potential lead compound for chlorine toxicityU01ES033265 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AGGARWAL, SAURABH · 2021 to 2023
$1.3M
Sickle Cell Trait Mice are More Susceptible to Chlorine Exposure and Haptoglobin Improves the OutcomesR21ES034226 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI ALISHLASH, AMMAR · 2022 to 2024
$594k
Children's of AlabamaNational Center on Minority Health and Health Disparities U54MD000502NIDA NIH HHS 7R01DA049657NIDA NIH HHS R01 DA049657NIEHS NIH HHS 1R21ES034226-01NIEHS NIH HHS R21 ES034226NIEHS NIH HHS U01 ES033265NIMHD NIH HHS U54 MD000502
6 · The paper itself

Abstract

backgroundAcute Chest Syndrome (ACS) is the leading cause of death in children with sickle cell disease (SCD) in the US-about half of the children who develop ACS present initially with pain.

methodsHere, we studied biomarkers to differentiate ACS from vaso-occlusive crises (VOC) in children with SCD who presented with pain to the emergency department (ED). We conducted a prospective cohort study of consecutive patients who presented to the ED with pain and were discharged with ACS or VOC between March, 2017 and February, 2020.

resultsWe identified 7 patients with ACS and 19 patients with VOC. The two groups were comparable in age and sex. All patients with ACS had asthma versus 42% of the VOC group. The ACS group had lower weight and BMI z-scores. Patients with ACS compared to VOC had significantly higher respiratory rates, lower O

conclusionsWe identified biomarkers associated with ACS development in children with SCD presenting with pain that allow for earlier ACS interventions to reduce mortality and morbidity.

Indexed as

Acute Chest SyndromeAnemia, Sickle CellBiomarkersAdolescentChildChild, PreschoolDiagnosis, DifferentialFemaleHumansMaleProspective StudiesBiomarkersbiomarkersdiagnosispainpediatricrespiratorysickle cell diseasevaso‐occlusive crisis acute chest syndrome

Identifiers

PMID39498599
PMCPMC11710972

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.