Evidence map›Paper›PMID 39498416›Full record

ArticleJournal of the Endocrine Society2024

Effect of Mutation Type on Ectopic Ossification Among Adult Patients With X-Linked Hypophosphatemia.

Hajime Kato, Yasuki Ishihara, Yasuhisa Ohata, Koki Irie, So Watanabe, Soichiro Kimura, Yoshitomo Hoshino, Naoko Hidaka, Yuka Kinoshita, Yuki Taniguchi and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hajime KatoDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0001-9178-7846
Yasuki IshiharaDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Yasuhisa OhataDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Koki IrieDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
So WatanabeOsteoporosis Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Soichiro KimuraDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Yoshitomo HoshinoDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-5226-2227
Naoko HidakaDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-5450-2247
Yuka KinoshitaDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-6583-0879
Yuki TaniguchiDepartment of Orthopedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-2329-123X
Hiroshi KobayashiDepartment of Orthopedic Surgery, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Demetrios T BraddockDepartment of Pathology, Yale University, New Haven, CT 06510, USA.
Takuo KubotaDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.ORCID https://orcid.org/0000-0003-4483-4405
Keiichi OzonoDepartment of Pediatrics, Osaka University Graduate School of Medicine, Suita 565-0871, Japan.
Masaomi NangakuDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0001-7401-2934
Noriko MakitaDivision of Nephrology and Endocrinology, The University of Tokyo Hospital, Tokyo 113-8655, Japan.
Nobuaki ItoOsteoporosis Center, The University of Tokyo Hospital, Tokyo 113-8655, Japan.ORCID https://orcid.org/0000-0002-4071-5372

Funding

ENPP1 regulation of mammalian bone massR01AR080416 · NIAMS · YALE UNIVERSITY · PI DEMETRIOS BRADDOCK · 2022 to 2026
$2.3M
NIAMS NIH HHS R01 AR080416
6 · The paper itself

Abstract

Context: Causative factors for ectopic ossifications in X-linked hypophosphatemia (XLH) remain to be elucidated. Objective: This work aimed to investigate the genotype-phenotype correlations between the phosphate-regulating endopeptidase homologue, X-linked gene ( Methods: Biochemical data, spinal computed tomography scans, and x-rays of hip/knee joints were retrospectively reviewed. Genetic analysis and the measurement of plasma inorganic pyrophosphate (PP Results: We examined 24 distinct pathogenic Conclusion: Neither modeling found correlates between PHEX pathogenic variants and ectopic ossification. The effects of PP

Indexed as

ectopic ossificationOPLLPHEXpyrophosphateX-linked hypophosphatemia

Identifiers

PMID39498416
PMCPMC11532897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.